CAS 78755-81-4 Pharmaceutical Raw Materials Flumazenil For Nootropic Supplement
Supériorité
Zhongshan Latterson Biotechnology Co., Ltd., est une entreprise pharmaceutique complète, qui s'est spécialisé dans la technologie biopharmaceutique 7 années. L'entreprise est située dans la ville de Zhongshan, Province de Guangdong , Chine.
Notre usine couvre une superficie de 33500 mètres carrés, avec un environnement propre et une belle mise en page. Il existe plusieurs ateliers de grande ou moyenne taille et un centre d'assurance qualité et de recherche avec un équipement de pointe. Maintenant, nos principaux produits sont des séries de stéroïdes anabolisants, Série peptidique, Série d'anesthésie locale. Nos produits atteignent le niveau avancé du marché intérieur, dont beaucoup atteignent la norme internationale, les certificats contiennent: KASCHER , ISO 9001:2008 , BPF , SGS.
Nom du produit |
Flumazenil |
Alias |
Romazicon |
Synonymes |
Ethyl 8-fluoro-5-methyl-6-oxo-5, 6-dihydro-4h-imidazo[1, 5-un][1, 4]benzodiazepine-3-carboxylate; FLUMAZENIL; 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1, 5-UN][1, 4]BENZO-DIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER; 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1, 5-UN][1, 4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL EST; 4H-IMIDAZO[1, 5-UN][1, 4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-, ETHYL ESTER; RO 15-1788; Flumazenil, Flumazepil; FlumazenilUsDmf |
CAS |
78755-81-4 |
Pureté |
99.0% |
Classe |
Qualité pharmaceutique |
Marque |
STEROID |
MF. |
C15H14FN3O3 |
M.W. |
303.29 |
Apparence |
White power |
Catégories |
Active Pharmaceutical Ingredients; GABA/Glycine receptor; GABA; Amines; Hétérocycles; Intermédiaires & Produits chimiques raffinés, produits chimiques en bon état; Médicaments; ZEBETA; Autres API; Antagonist; API |
Propriétés |
Colourless crystals |
Espace de rangement |
Original package at cool dark place
Fumazenil is an imidazobenzodiazepine derivative.
Fumazenil a potent benzodiazepine receptor antagonist. |
La description:
Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective receptor antagonist primarily available by injection only, and the only GABAA negative allosteric modulator on the market today. It has antagonistic and antidote properties , through competitive inhibition. It was first introduced in 1987 by Hoffmann-La Roche under the trade name Anexate, but only approved by the FDA on December 20, 1991. Flumazenil went off patent in 2008, so at present generic formulations of this drug are available. Intravenous flumazenil is primarily used to treat overdoses and to help reverse anesthesia. Administration of flumazenil by sublingual lozenge and topical cream has also been tested.
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. Reversing drowsiness, sedation, and other effects caused by benzodiazepine Flumazenil is a benzodiazepine antagonist. It works by blocking receptors in the brain and central nervous system that benzodiazepine need to reach to be active, which helps reduce drowsiness and sedation.
Applications:
Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures. It has been used as an antidote in the treatment of benzodiazepine overdoses.It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil’s short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
It is also sometimes used to reverse the effects of benzodiazepines after surgery in a manner similar to naloxone’s application to reverse the effect of opiates and opioid following surgery. This requires careful monitoring by an anesthesiologist due to potential side effects and serious risks associated with both over-administering flumazenil and the removal of patient life-support and monitoring equipment before the benzodiazepines have worn off (due to flumazenil masking their continued effect).
Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zol-pidem,. It may also be effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia. It has also been used in hepatic encephalopathy, though results have been mixed. The onset of action is rapid and usually effects are seen within one to two minutes. The peak effect is seen at six to ten minutes. The recommended dose for adults is 200 μg every 1-2 minutes until the effect is seen, to a maximum of 3 mg per hour. It is available as a clear, colourless solution for intravenous injection, contenant 500 μg in 5 mL.
Half life:
Initial distribution half-life is 4 à 11 minutes and the terminal half-life is 40 à 80 minutes. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 à 75 minutes).
Benefits and Effects:
Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepine are used for either diagnostic or therapeutic procedures. It has been used as an antidote in the treatment of benzodiazepine overdoses. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil’s short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms. Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.
certificat d'authenticité:
Éléments d'analyse |
spécification |
Résultats |
Apparence |
Poudre cristalline blanche |
Poudre cristalline blanche |
Identification |
The sample’s IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation |
Conforme |
Point de fusion |
198ºC to 202ºC |
200.6ºC to 200.9ºC |
apparence de la solution |
The solution is clear and is not Intenser than reference solution BY7 |
Conforme |
Impurity C |
NMT 0.2% |
0.02% |
Impurity A |
NMT 0.10% |
Not detected |
Impurity B |
NMT 0.2% |
0.03% |
Impurity D |
NMT 0.10% |
0.03% |
Impurity E |
NMT 0.10% |
Not detected |
Impurity F |
NMT 0.10% |
Not detected |
Individual unknown impurituy |
NMT 0.10% |
0.02% |
Impuretés totales |
NMT 0.5% |
0.1% |
Perte au séchage |
NMT 0.5% |
0.2% |
Cendres sulfatées |
NMT 0.1% |
0.05% |
Métaux lourds |
≤0.5 ppm |
5ppm |
Microbial limits
(for Injection) |
Bacteria not more than 50CFU/g |
<10 CFU/g |
Microbial limits |
Mildew and microzyme not more than 50CFU/g |
<10 CFU/g |
Microbial limits |
Escherichia coli absence |
Absence |
Éthanol |
NMT2000ppm |
Not detected |
Chloroform |
NMT30ppm |
Not detected |
Acetic acid |
NMT4000ppm |
Not detected |
Dichloromethane |
NMT600ppm |
<0.002% |
Ethyl ethanoate |
NMT5000ppm |
<0.003% |
DMF |
NMT750ppm |
Not detected |
Essai (On dried substance) |
98.0-102.0% |
99.80% |
Bacterial endotoxins |
pas plus de 25.0 USP Endotoxin Units per mg of flumazenil. |
pas plus de 8.0 USP Endotoxin Units per mg of flumazenil. |
Guarantees the nature time |
36 mois |
36 mois |
Notre service
1.100% La politique de réexpédition est notre base commerciale. 100% de réexpédition immédiatement si votre colis reste en douane pendant 4 jours et n'est pas mis à jour.
2.Remboursement total pour 15 jours d'insatisfaction avec la qualité.
3.Nous pouvons fournir des échantillons gratuits.
4.Nous avons un emballage spécial ,Il peut être facilement passé à la douane. Il sera plus sûr.
5.Notre société coopère à long terme avec DHL.EMS.Fedex et ainsi de suite. Il peut être envoyé à votre main plus rapidement. La photo du colis doit être offerte dans les 12 heures suivant la réception de votre paiement de stéroïdes.
6.Si vous avez la chance de venir en Chine. Je peux te montrer notre labo.
7.Notre société a WU, MG, TT, et les moyens de paiement Bitcoin à l'avance. Vous pouvez payer 95% pour les peptides coûtent au début pour la commande, le reste peut nous offrir dans votre prochaine commande;
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