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  • CAS 78755-81-4 Pharmaceutical Raw Materials Flumazenil For Nootropic Supplement

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    Other Hot-Sale Products (Raw Powder)
    Model Number : CAS: 78755-81-4
    Certification : GMP,SGS,ISO9001:2008,KOSHER
    Place of Origin : China
    MOQ : 10g
    Price : Negotiable
    Payment Terms : Western Union, MoneyGram, Bank Transfer, Bitcoin
    Supply Ability : 3000KG/Month
    Delivery Time : Usually within 7 work days
    Packaging Details : Stealth and discreet packaging
    Product Name : Flumazenil
    CAS : 78755-81-4
    MF : C15H14FN3O3
    MW : 303.29
    Purity : 99.0%
    appearance : White Powder
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    • Specifications

    CAS 78755-81-4 Pharmaceutical Raw Materials Flumazenil For Nootropic Supplement

    Superiority

    Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
    Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.

    Product Name Flumazenil
    Alias Romazicon
    Synonyms Ethyl 8-fluoro-5-methyl-6-oxo-5, 6-dihydro-4h-imidazo[1, 5-a][1, 4]benzodiazepine-3-carboxylate; FLUMAZENIL; 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1, 5-A][1, 4]BENZO-DIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER; 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1, 5-A][1, 4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL EST; 4H-IMIDAZO[1, 5-A][1, 4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-, ETHYL ESTER; RO 15-1788; Flumazenil, Flumazepil; FlumazenilUsDmf
    CAS 78755-81-4
    Purity 99.0%
    Grade Pharmaceutical Grade
    Brand Name STEROID
    M.F. C15H14FN3O3
    M.W. 303.29
    Appearance White power
    Categories Active Pharmaceutical Ingredients; GABA/Glycine receptor; GABA; Amines; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; ZEBETA; Other APIs; Antagonist; API
    Properties Colourless crystals
    Storage Original package at cool dark place

    Fumazenil is an imidazobenzodiazepine derivative.

    Fumazenil a potent benzodiazepine receptor antagonist.

    Description:

    Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective receptor antagonist primarily available by injection only, and the only GABAA negative allosteric modulator on the market today. It has antagonistic and antidote properties , through competitive inhibition. It was first introduced in 1987 by Hoffmann-La Roche under the trade name Anexate, but only approved by the FDA on December 20, 1991. Flumazenil went off patent in 2008, so at present generic formulations of this drug are available. Intravenous flumazenil is primarily used to treat overdoses and to help reverse anesthesia. Administration of flumazenil by sublingual lozenge and topical cream has also been tested.

    Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. Reversing drowsiness, sedation, and other effects caused by benzodiazepine Flumazenil is a benzodiazepine antagonist. It works by blocking receptors in the brain and central nervous system that benzodiazepine need to reach to be active, which helps reduce drowsiness and sedation.

    Applications:

    Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures. It has been used as an antidote in the treatment of benzodiazepine overdoses.It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil’s short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.

    It is also sometimes used to reverse the effects of benzodiazepines after surgery in a manner similar to naloxone’s application to reverse the effect of opiates and opioid following surgery. This requires careful monitoring by an anesthesiologist due to potential side effects and serious risks associated with both over-administering flumazenil and the removal of patient life-support and monitoring equipment before the benzodiazepines have worn off (due to flumazenil masking their continued effect).

    Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zol-pidem,. It may also be effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia. It has also been used in hepatic encephalopathy, though results have been mixed. The onset of action is rapid and usually effects are seen within one to two minutes. The peak effect is seen at six to ten minutes. The recommended dose for adults is 200 μg every 1-2 minutes until the effect is seen, to a maximum of 3 mg per hour. It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5 mL.

    Half life:

    Initial distribution half-life is 4 to 11 minutes and the terminal half-life is 40 to 80 minutes. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 minutes (range: 20 to 75 minutes).

    Benefits and Effects:

    Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepine are used for either diagnostic or therapeutic procedures. It has been used as an antidote in the treatment of benzodiazepine overdoses. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil’s short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms. Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.

    COA:

    Items of analysis Specification Results
    Appearance White crystalline powder White Crystalline Powder
    Identification The sample’s IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation Conforms
    Melting point 198ºC to 202ºC 200.6ºC to 200.9ºC
    Appearance of solution The solution is clear and is not Intenser than reference solution BY7 Conforms
    Impurity C NMT 0.2% 0.02%
    Impurity A NMT 0.10% Not detected
    Impurity B NMT 0.2% 0.03%
    Impurity D NMT 0.10% 0.03%
    Impurity E NMT 0.10% Not detected
    Impurity F NMT 0.10% Not detected
    Individual unknown impurituy NMT 0.10% 0.02%
    Total impurities NMT 0.5% 0.1%
    Loss on drying NMT 0.5% 0.2%
    Sulphated ash NMT 0.1% 0.05%
    Heavy metals ≤0.5 ppm 5ppm
    Microbial limits
    (for Injection)
    Bacteria not more than 50CFU/g <10 CFU/g
    Microbial limits Mildew and microzyme not more than 50CFU/g <10 CFU/g
    Microbial limits Escherichia coli absence Absence
    Ethanol NMT2000ppm Not detected
    Chloroform NMT30ppm Not detected
    Acetic acid NMT4000ppm Not detected
    Dichloromethane NMT600ppm <0.002%
    Ethyl ethanoate NMT5000ppm <0.003%
    DMF NMT750ppm Not detected
    Assay (On dried substance) 98.0-102.0% 99.80%
    Bacterial endotoxins not more than 25.0 USP Endotoxin Units per mg of flumazenil. not more than 8.0 USP Endotoxin Units per mg of flumazenil.
    Guarantees the nature time 36 months 36 months

    Our service

    1.100% reshipment policy is our business basic.100% reshipment immediately if your parcel stays Customs for 4 days and doesn’t get updated.
    2.Total refund for 15 days of dissatisfaction with quality.
    3.We can provide free samples.
    4.We have a special packing ,It can be easily passed through the customs.It will be more safe.
    5.Our company have a long term cooperate with DHL.EMS.Fedex and so on .It can be sent to your hand more quickly. Parcel photo should be offered within 12hours after receiving your steroid payment.
    6.If you have a chance to come to China. I can show you our lab.
    7.Our company has WU, MG, TT, and Bitcoin payment ways in advance.You can pay 95% for the peptides cost at first for order, the rest can offer us in your next order;

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