Zhongshan Latterson Biotechnology Co., GmbH.
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  • FALL 78755-81-4 Pharmaceutical Raw Materials Flumazenil For Nootropic Supplement

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    Andere Hot-Sale-Produkte (Rohpulver)
    Modell-Nr : FALL: 78755-81-4
    Zertifizierung : GMP,SGS,ISO9001:2008,KOSCHER
    Herkunftsort : China
    MOQ : 10g
    Preis : Verhandelbar
    Zahlungsbedingungen : Western Union, MoneyGram, Banküberweisung, Bitcoin
    Lieferfähigkeit : 3000KG/Monat
    Lieferzeit : Usually within 7 Arbeitstage
    Verpackungsinformationen : Stealth and discreet packaging
    Produktname : Flumazenil
    FALL : 78755-81-4
    MF : C15H14FN3O3
    MW : 303.29
    Reinheit : 99.0%
    Aussehen : Weißes Puder
    Anfrage
    • Spezifikationen

    FALL 78755-81-4 Pharmaceutical Raw Materials Flumazenil For Nootropic Supplement

    Überlegenheit

    Zhongshan Latterson Biotechnology Co., GmbH., ist ein umfassendes Pharmaunternehmen, die sich auf biopharmazeutische Technologie spezialisiert haben 7 Jahre. Das Unternehmen befindet sich in der Stadt Zhongshan, Provinz Guangdong , China.
    Unsere Fabrik umfasst eine Fläche von 33500 Quadratmeter, mit sauberer Umgebung und schönem Layout. Es gibt mehrere große oder mittlere Werkstätten und ein QS- und Forschungszentrum mit fortschrittlicher Ausrüstung. Derzeit, Unsere Hauptprodukte sind anabole Steroide, Peptid-Serie, Lokalanästhesie-Serie. Unsere Produkte erreichen den fortgeschrittenen Standard des heimischen Marktes, viele davon erreichen den internationalen Standard, Zertifikate enthalten: KOSCHER , ISO 9001:2008 , GMP , SGS.

    Produktname Flumazenil
    Alias Romazicon
    Synonyme Ethyl 8-fluoro-5-methyl-6-oxo-5, 6-dihydro-4h-imidazo[1, 5-a][1, 4]benzodiazepine-3-carboxylate; FLUMAZENIL; 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1, 5-EIN][1, 4]BENZO-DIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER; 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1, 5-EIN][1, 4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL EST; 4H-IMIDAZO[1, 5-EIN][1, 4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5, 6-DIHYDRO-5-METHYL-6-OXO-, ETHYL ESTER; RO 15-1788; Flumazenil, Flumazepil; FlumazenilUsDmf
    FALL 78755-81-4
    Reinheit 99.0%
    White Powder Muscle Building Steroide Epiandrosteron White Powder Muscle Building Steroide Epiandrosteron
    Markenname STEROID
    M.F. C15H14FN3O3
    M.W. 303.29
    Aussehen White power
    Kategorien Aktive pharmazeutische Inhaltsstoffe; GABA/Glycin-Rezeptor; GABA; Amine; Heterocyclen; Zwischenprodukte & Feinchemikalien; Arzneimittel; ZEBETA; Andere APIs; Antagonist; API
    Eigenschaften Colourless crystals
    Lagerung Original package at cool dark place

    Fumazenil is an imidazobenzodiazepine derivative.

    Fumazenil a potent benzodiazepine receptor antagonist.

    Beschreibung:

    Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective receptor antagonist primarily available by injection only, and the only GABAA negative allosteric modulator on the market today. It has antagonistic and antidote properties , through competitive inhibition. It was first introduced in 1987 by Hoffmann-La Roche under the trade name Anexate, but only approved by the FDA on December 20, 1991. Flumazenil went off patent in 2008, so at present generic formulations of this drug are available. Intravenous flumazenil is primarily used to treat overdoses and to help reverse anesthesia. Administration of flumazenil by sublingual lozenge and topical cream has also been tested.

    Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. Reversing drowsiness, sedation, and other effects caused by benzodiazepine Flumazenil is a benzodiazepine antagonist. It works by blocking receptors in the brain and central nervous system that benzodiazepine need to reach to be active, which helps reduce drowsiness and sedation.

    Anwendungen:

    Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures. It has been used as an antidote in the treatment of benzodiazepine overdoses.It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil’s short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.

    It is also sometimes used to reverse the effects of benzodiazepines after surgery in a manner similar to naloxone’s application to reverse the effect of opiates and opioid following surgery. This requires careful monitoring by an anesthesiologist due to potential side effects and serious risks associated with both over-administering flumazenil and the removal of patient life-support and monitoring equipment before the benzodiazepines have worn off (due to flumazenil masking their continued effect).

    Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zol-pidem,. It may also be effective in reducing excessive daytime sleepiness while improving vigilance in primary hypersomnias, such as idiopathic hypersomnia. It has also been used in hepatic encephalopathy, though results have been mixed. The onset of action is rapid and usually effects are seen within one to two minutes. The peak effect is seen at six to ten minutes. The recommended dose for adults is 200 μg every 1-2 minutes until the effect is seen, bis maximal 3 mg per hour. It is available as a clear, colourless solution for intravenous injection, enthaltend 500 μg in 5 ml.

    Halbwertzeit:

    Initial distribution half-life is 4 zu 11 minutes and the terminal half-life is 40 zu 80 Protokoll. Prolongation of the half-life to 1.3 hours in patients with moderate hepatic impairment and 2.4 hours in severely impaired patients. Compared to adults, the elimination half-life in pediatric patients was more variable, averaging 40 Protokoll (range: 20 zu 75 Protokoll).

    Benefits and Effects:

    Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepine are used for either diagnostic or therapeutic procedures. It has been used as an antidote in the treatment of benzodiazepine overdoses. There are many complications that must be taken into consideration when used in the acute care setting.These include lowered seizure threshold, agitation, and anxiousness. Flumazenil’s short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms. Flumazenil has been effectively used to treat overdoses of non-benzodiazepine hypnotics, such as zolpidem, zaleplon and zopiclone.

    Echtheitszertifikat:

    Elemente der Analyse Spezifikation Ergebnisse
    Aussehen weißes kristallines Pulver White Powder Muscle Building Steroide Epiandrosteron
    Identifizierung The sample’s IR spectrum is according with spectrum of Flumazenil,The retention time of the major peak Flumazenil in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation Entspricht
    Schmelzpunkt 198ºC to 202ºC 200.6ºC to 200.9ºC
    Aussehen der Lösung The solution is clear and is not Intenser than reference solution BY7 Entspricht
    Impurity C NMT 0.2% 0.02%
    Verunreinigung A NMT 0.10% Not detected
    Impurity B NMT 0.2% 0.03%
    Impurity D NMT 0.10% 0.03%
    Impurity E NMT 0.10% Not detected
    Impurity F NMT 0.10% Not detected
    Individual unknown impurituy NMT 0.10% 0.02%
    Total impurities NMT 0.5% 0.1%
    Trocknungsverlust NMT 0.5% 0.2%
    Sulfatasche NMT 0.1% 0.05%
    Schwermetalle ≤0.5 ppm 5ppm
    Microbial limits
    (for Injection)
    Bacteria not more than 50CFU/g <10 CFU/g
    Microbial limits Mildew and microzyme not more than 50CFU/g <10 CFU/g
    Microbial limits Escherichia coli absence Absence
    Äthanol NMT2000ppm Not detected
    Chloroform NMT30ppm Not detected
    Acetic acid NMT4000ppm Not detected
    Dichloromethane NMT600ppm <0.002%
    Ethyl ethanoate NMT5000ppm <0.003%
    DMF NMT750ppm Not detected
    Assay (On dried substance) 98.0-102.0% 99.80%
    Bacterial endotoxins nicht mehr als 25.0 USP Endotoxin Units per mg of flumazenil. nicht mehr als 8.0 USP Endotoxin Units per mg of flumazenil.
    Guarantees the nature time 36 Monate 36 Monate

    Unser Service

    1.100% Rücksendungspolitik ist unser Geschäft. 100% Rücksendung sofort, wenn Ihr Paket Zoll bleibt für 4 Tage und wird nicht aktualisiert.
    2.Gesamtrückerstattung für 15 Tage der Unzufriedenheit mit der Qualität.
    3.Wir können kostenlose Muster zur Verfügung stellen.
    4.Wir haben eine spezielle Verpackung ,Es kann leicht durch den Zoll geleitet werden. Es ist sicherer.
    5.Unsere Firma hat eine langfristige Zusammenarbeit mit DHL.EMS.Fedex und so weiter. Es kann schneller an Ihre Hand gesendet werden. Paketfoto sollte innerhalb von 12 Stunden nach Erhalt Ihrer Steroidzahlung angeboten werden.
    6.Wenn Sie die Chance haben, nach China zu kommen. Ich kann dir unser Labor zeigen.
    7.Unsere Firma hat WU, MG, TT, und Bitcoin-Zahlungsarten im Voraus. Sie können bezahlen 95% für die Peptide kosten zunächst die Bestellung, den Rest können Sie uns bei Ihrer nächsten Bestellung anbieten;

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