Lidocaine Base

Basic Details:

Product Name: Lidocaine

CAS: 137-58-6

MF: C14H22N2O

MW: 234.34

EINECS: 205-302-8

mp: 66-69°C

storage temp: Store at RT

solubility ethanol: 4 mg/mL

form: powder

Water Solubility: practically insoluble

Stability: Stable. Incompatible with strong oxidizing agents.

Usage: Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of

>32 μM.

Description:

Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic

drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations,

injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health

Organization’s List of Essential Medicines, a list of the most important medications needed in a

basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the

treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning,

cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated.

Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have

been initiated. A routine prophylactic administration is no longer recommended for acute cardiac

infarction; the overall benefit of this measure is not convincing.

Application:

Lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.

Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted

by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage

of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation,

yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological /

toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine.

Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and

less than 10% is excreted unchanged.

Lab Test Result: