Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4

Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4

Ketoprofen Basic information:
Name: Ketoprofen
CAS: 22071-15-4
MF: C16H14O3
MW: 254.28
Standard: USP
Purity: Pharmaceutical grade 99%
Appearance: white powder
chemical properties: White Crystalline Solid
Packing: 25KG / Fiber drum
Uses Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Uses Anti-inflammatory; analgesic

Pharmacodynamics

Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.

Mechanism of action

The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

CERTIFICATE OF ANALYSIS