Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4
Ketoprofen Basic information:
Nombre: ketoprofeno
CASO: 22071-15-4
MF: C16H14O3
MW: 254.28
Estándar: USP
Pureza: Grado farmacéutico 99%
Apariencia: polvo blanco
propiedades químicas: White Crystalline Solid
Embalaje: 25KG / Fiber drum
Uses Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Uses Anti-inflammatory; analgésico
Pharmacodynamics
Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dismenorrea, and alleviate moderate pain.
Mecanismo de acción
The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, g/kg en ratas, and subsequent heat dissipation.
CERTIFICADO DE ANÁLISIS
nombre del producto |
ketoprofeno |
Inspection Date |
2016.04.11 |
Manufacturing Date |
2016.04.07 |
Expire Date |
2018.04.06 |
Lot No. |
160401 |
Lot Size |
500KG |
TEST ITEM |
SPECIFICATIONS |
TEST RESULTS |
Apariencia |
Polvo cristalino blanco |
Polvo cristalino blanco |
Identificación |
Infrared Absorption |
Compares with Authentic
Spectrum (KBr) |
|
Ultraviolet Absorption |
Compares with AuthenticSpectrum |
Melting range |
92.0℃ – 97.0℃ |
92.4℃ – 93.5℃ |
Rotacion especifica |
-1° – +1° |
0.000° |
Pérdida por secado |
≤0,5% |
0.11% |
Residuos en ignición |
≤0.2% |
0.05% |
Metales pesados |
≤0.002% |
Ajustarse |
Individual Impurity |
≤0.2% |
0.07% |
Total Impurities |
≤1.0% |
0.28% |
Ensayo |
98.5% – 101.0% |
99.32% |
Conclusión |
The above product complies with the standard of USP37 |