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  • Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4

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    • Specifications

    Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4

     

    Ketoprofen Basic information:
    Name: Ketoprofen
    CAS: 22071-15-4
    MF: C16H14O3
    MW: 254.28
    Standard: USP
    Purity: Pharmaceutical grade 99%
    Appearance: white powder
    chemical properties: White Crystalline Solid
    Packing: 25KG / Fiber drum
    Uses Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
    Uses Anti-inflammatory; analgesic

     

    Pharmacodynamics

    Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.

    Mechanism of action

    The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

    CERTIFICATE OF ANALYSIS

     

    Product Name Ketoprofen Inspection Date 2016.04.11
    Manufacturing Date 2016.04.07 Expire Date 2018.04.06
    Lot No. 160401 Lot Size 500KG

     

    TEST ITEM SPECIFICATIONS TEST RESULTS
    Appearance White crystalline powder White crystalline powder
    Identification Infrared Absorption Compares with Authentic

    Spectrum (KBr)

      Ultraviolet Absorption Compares with AuthenticSpectrum
    Melting range 92.0℃ – 97.0℃ 92.4℃ – 93.5℃
    Specific rotation -1° – +1° 0.000°
    Loss on drying ≤0.5% 0.11%
    Residue on Ignition ≤0.2% 0.05%
    Heavy metals ≤0.002% Conform
    Individual Impurity ≤0.2% 0.07%
    Total Impurities ≤1.0% 0.28%
    Assay 98.5% – 101.0% 99.32%
    Conclusion The above product complies with the standard of USP37

     

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