Ketoprofen Pharmaceutical Raw Materials CAS 22071-15-4
Ketoprofen Basic information:
Name: Ketoprofen
CAS: 22071-15-4
MF: C16H14O3
MW: 254.28
Standard: USP
Purity: Pharmaceutical grade 99%
Appearance: white powder
chemical properties: White Crystalline Solid
Packing: 25KG / Fiber drum
Uses Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Uses Anti-inflammatory; analgesic
Pharmacodynamics
Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.
Mechanism of action
The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
CERTIFICATE OF ANALYSIS
Product Name |
Ketoprofen |
Inspection Date |
2016.04.11 |
Manufacturing Date |
2016.04.07 |
Expire Date |
2018.04.06 |
Lot No. |
160401 |
Lot Size |
500KG |
TEST ITEM |
SPECIFICATIONS |
TEST RESULTS |
Appearance |
White crystalline powder |
White crystalline powder |
Identification |
Infrared Absorption |
Compares with Authentic
Spectrum (KBr) |
|
Ultraviolet Absorption |
Compares with AuthenticSpectrum |
Melting range |
92.0℃ – 97.0℃ |
92.4℃ – 93.5℃ |
Specific rotation |
-1° – +1° |
0.000° |
Loss on drying |
≤0.5% |
0.11% |
Residue on Ignition |
≤0.2% |
0.05% |
Heavy metals |
≤0.002% |
Conform |
Individual Impurity |
≤0.2% |
0.07% |
Total Impurities |
≤1.0% |
0.28% |
Assay |
98.5% – 101.0% |
99.32% |
Conclusion |
The above product complies with the standard of USP37 |