Zhongshan Latterson Biotechnology Co., Ltd.

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CAS 1195765-45-7 Pharmaceutical Raw Materials Kinase Inhibitors Tafinlar

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Model Number : CAS: 1195765-45-7
Certification : GMP,SGS,ISO9001:2008,KOSHER
Place of Origin : China
MOQ : 10g
Price : Negotiable
Payment Terms : Western Union, MoneyGram, Bank Transfer, Bitcoin
Supply Ability : 3000KG/Month
Delivery Time : Usually within 7 work days
Packaging Details : Stealth and discreet packaging
Product Name : Dabrafenib
Assay : 99% min
CAS : 1195765-45-7
Molecular formula : C23H20F3N5O2S2
Molecular Weight : 519.5624096
Appearance : White to slightly yellowish-white crystalline
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CAS 1195765-45-7 Pharmaceutical Raw Materials Kinase Inhibitors Tafinlar

Superiority

Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.

Product Details:

Product Name Dabrafenib
CAS 1195765-45-7
Assay 99% min
Synonyms Dabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib free base(GSK2118436A);Dabrafenib(GSK2118436);GSK2118436A;Dabrafenib (GSK2118436);Dabrafenib KB-57246;Debrafenib API
MF C23H20F3N5O2S2
MW 519.5624096
EINECS 200-366-3
Appearance White to slightly yellowish-white crystalline
Storage Shading, confined preservation
Category Raf B protein kinase inhibitor;inhibitor;MAPK;Inhibitors

Description:

Dabrafenib (trade name GSK2118436, Tafinlar) is a drug for the treatment of cancers associated with a mutated version of the gene BRAF. Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.

The Food and Drug Administration initially approved dabrafenib as a single agent treatment for patients with BRAF V600Emutation-positive advanced melanoma on May 30, 2013.Clinical trial data demonstrated that resistance to dabrafinib and other BRAF inhibitors occurs within 6 to 7 months.To overcome this resistance, the BRAF inhibitor dabrafenib was combined with the MEK inhibitor trametinib.On January 8, 2014, the FDA approved this combination of dabrafenib and trametinib for BRAF V600E/K-mutant metastatic melanoma.

Application:

Dabrafenib is used to treat a certain type of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Dabrafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Dosage:

Patients were randomized to receive trametinib 2 mg orally once daily in combination with dabrafenib 150 mg orally twice daily (n=54), trametinib 1 mg orally once daily in combination with dabrafenib 150 mg orally twice daily (n=54), or single-agent dabrafenib 150 mg orally twice daily (n=54).

The recommended dose and schedule for trametinib and dabrafenib when used in combination is trametinib 2 mg orally once daily with dabrafenib 150 mg orally twice daily continued until disease progression or unacceptable toxicity occurs. Trametinib and dabrafenib should be taken at least one hour before or two hours after a meal. The once daily dose of trametinib can be taken at the same time as either dose of dabrafenib.

Our service

1.100% reshipment policy is our business basic.100% reshipment immediately if your parcel stays Customs for 4 days and doesn’t get updated.
2.Total refund for 15 days of dissatisfaction with quality.
3.We can provide free samples.
4.We have a special packing ,It can be easily passed through the customs.It will be more safe.
5.Our company have a long term cooperate with DHL.EMS.Fedex and so on .It can be sent to your hand more quickly. Parcel photo should be offered within 12hours after receiving your steroid payment.
6.If you have a chance to come to China. I can show you our lab.
7.Our company has WU, MG, TT, and Bitcoin payment ways in advance.You can pay 95% for the peptides cost at first for order, the rest can offer us in your next order;

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