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Description:

Sildenafil, sold as Viagra and other trade names, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. Its use for sexual dysfunction in women is not clear.

Common side effects include headaches and heart burn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin, as this may result in a severe and potentially fatal drop in blood pressure.

It acts by inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.

It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett.[2][3] Since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (Cialis) and vardenafil (Levitra).

The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction including for those with diabetes mellitus.

Pulmonary hypertension

As well as erectile dysfunction, sildenafil citrate is also effective in the rare disease pulmonary arterial hypertension. It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, sildenafil acts selectively in both these areas without inducing vasodilation in other areas of the body. Pfizer submitted an additional registration for sildenafil to the United States Food and Drug Administration (FDA), and sildenafil was approved for this indication in June 2005. The preparation is named Revatio, to avoid confusion with Viagra, and the 20-mg tablets are white and round. Sildenafil joins bosentan and prostacyclin-based therapies for this condition.

Applications:

Sildenafil citrate 100 mg starting dose in men with erectile dysfunction in an international, double-blind, placebo-controlled study: effect on the sexual experience and reducing feelings of anxiety about the next intercourse attempt.

Viagra treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours. The most common side effects of Viagra are headache, facial flushing, and upset stomach. Rarely, blurred vision, or sensitivity to light may briefly occur.

As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, it relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.

Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.

Technical Data: In studies where Viagra was administered to over 3700 patients, 19-87 years old in world wide clinical trials. More than 550 patients received treatment post 1 year. 2.5% of the Viagra subjects and 2.3% of the placebo subjects reported adverse effects, which were all considered mild. These reported side effects included abnormal or blurred vision and increased sensitivity to light.

All other negative reactions reported, including URI, flu symptoms, back pain and arthralgia, occurred at a rate of less than 2% and equally common in the placebo and Viagra administered groups. Effects worsened and were reported more frequently as dosages increased.

Other studies measured duration of sexually stimulated erection using a Rigiscan device. Duration of rigidity was increased by 60% with Viagra use.

Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.

How does Sildenafil Citrate work?
This medication is known as a phosphodiesterase (PDE5) inhibitor. In combination with sexual stimulation, it helps the male organ fill with enough blood to cause an erection. The sexual arousal is absolutely necessary for the medication to show its positive effects. Once sex is over, the erection will go away.

Sildenafil viagra benefits:

1). “Viagra” redirects here. For other uses, see Viagra (disambiguation).

Sildenafil citrate——sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett.

2). Sexual dysfunction——The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.

3). Pulmonary hypertension—–As well as erectile dysfunction, sildenafil citrate is also effective in the rare disease pulmonary arterial hypertension (PAH). It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure.

4). Altitude sickness——-Sildenafil has been shown to be useful for the prevention and treatment of high-altitude pulmonary edema associated with altitude sickness such as that suffered by mountain climbers. While this effect has only recently been discovered, sildenafil is already becoming an accepted treatment for this condition, in particular in situations where the standard treatment of rapid descent has been delayed for some reason.

Our service

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