White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

Основная информация

Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations
наименование товара: Фенацетин
Синонимы: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4′-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
КЕЙС: 62-44-2
MF: C10H13NO2
МВт: 179.22
EINECS: 200-533-0
категории товаров: Другие API;Органика;Amines;» Жидкие инъекционные стероиды;» Жидкие инъекционные стероиды & » Жидкие инъекционные стероиды;Фармацевтические препараты
Мол файл: 62-44-2.моль
Phenacetin Structure
Phenacetin Chemical Properties
Температура плавления 133-136 ° C(горит)
Точка кипения 132 ° C / 4мм рт. ст.
Fp 2℃
температура хранения. 2-8° C
форма порошка
color White
Растворимость воды 0.076 г/100 мл
Sensitive Hygroscopic
Merck 14,7204
БРН 1869238
Стабильность: Стабильный. Несовместим с сильными окислителями, strong acids.

2. Описания:

Фенацетин – обезболивающее и жаропонижающее средство., widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, который заменил его в некоторых безрецептурных лекарствах после запрета на фенацетин..

3. Приложения:

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an “A.P.C.” or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent’s APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).

It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche’s Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin’s carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.

Phenacetin COA