White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

White Flash Scaly Crystalline Powder Phenacetin Anti Inflammatory Pain Relieving Drugs CAS 62-44-2

Basic information

Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics. Phenacetin also was once used as a stabilizer for hydrogen peroxide in hair-bleaching preparations
Nom du produit: Phénacétine
Synonymes: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4′-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
catégories de produits: Autres API;Organics;Amines;Aromatiques;Intermédiaires & Produits chimiques raffinés, produits chimiques en bon état;Médicaments
Fichier Mol: 62-44-2.mol
Phenacetin Structure
Phenacetin Chemical Properties
Point de fusion 133-136 °C(lit.)
Point d'ébullition 132 °C / 4mmHg
Fp 2℃
température de stockage. 2-8°C
former de la poudre
color White
Solubilité dans l'eau 0.076 g/100 mL
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Stabilité: Stable. Incompatible avec les agents oxydants forts, strong acids.

2. Descriptions:

La phénacétine est un médicament analgésique et antipyrétique, largement utilisé depuis son introduction en 1887 jusqu'à ce qu'il soit interdit aux États-Unis par la FDA en 1983. Son utilisation a diminué en raison de ses effets indésirables, qui comprennent un risque accru de certains cancers et de lésions rénales. Il est métabolisé en paracétamol, qui l'a remplacé dans certains médicaments en vente libre suite à l'interdiction de la phénacétine.

3. Applications:

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an “A.P.C.” or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent’s APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).

It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche’s Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin’s carcinogenicity.

La phénacétine est maintenant utilisée comme agent de coupe pour falsifier la cocaïne au Royaume-Uni et au Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. C'est un composé idéal pour ce type de recherche.

Phenacetin COA