Pirfenidone Raw powder CAS 53179-13-8 » Жидкие инъекционные стероиды
Краткая информация:
наименование товара: Пирфенидон
Синонимы: amr-69
КЕЙС: 53179-13-8
MF: C12H11NO
МВт: 185.22
mp: 96-97° C
температура хранения: Магазин в РТ
растворимость ДМСО: ≥10 mg/mL, растворимый
появление: Кремовый однотонный
Описание:
В пробирке, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF – бета – 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF – бета – 1 inducing fibroblast proliferation. In hamster model, pirfenidone, взято в рот, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.
Пирфенидон 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
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