Pirfenidone Raw powder CAS 53179-13-8 Culturismo Entrega Rápida y Segura
Detalle rápido:
nombre del producto: Pirfenidona
Sinónimos: amr-69
CASO: 53179-13-8
MF: C12H11NO
MW: 185.22
Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide: 96-97° C
temperatura de almacenamiento: Store at RT
solubilidad DMSO: ≥10 mg/mL, soluble
apariencia: Sólido blanquecino
Descripción:
In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF – beta – 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF – beta – 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.
Pirfenidona 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
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