Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone

Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone

Описание:

Имя: Пирфенидон
· при необходимости подогрейте смесь, поместив флакон в сковороду и поставив его на глазок плиты;: 5-methyl-1-phenylpyridin-2(1ЧАС)-один
CAS#: 53179-13-8
Молекулярная формула: C12H11NO
Молекулярный вес: 185.222
Плотность: 1.138
Температура плавления: 96-97ºC
Точка кипения: 329.1ºC
InChI=1/C25H36O3/c1-3-4-5-6-7-24: 152.7ºC
Растворимость: soluble in DMSO
Появление: off-white solid
Чистота: 99%

Описание:

В пробирке, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF – бета – 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF – бета – 1 inducing fibroblast proliferation. In hamster model, pirfenidone, взято в рот, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.

Пирфенидон 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

заявка:

pirfenidone is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.