Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone

Anti-Inflammatory Pharmaceutical Raw Powder Pirfenidone

Descripción:

Nombre: Pirfenidona
· recalentar la mezcla si es necesario colocando el vial en una sartén y colocarlo sobre el ojo de la estufa · colocar un: 5-methyl-1-phenylpyridin-2(1H)-uno
CAS#: 53179-13-8
Fórmula molecular: C12H11NO
Peso molecular: 185.222
Densidad: 1.138
Punto de fusion: 96-97C
Punto de ebullición: 329.1C
punto de inflamabilidad: 152.7C
Solubilidad: soluble in DMSO
Apariencia: off-white solid
Pureza: 99%

Descripción:

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF – beta – 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF – beta – 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.

Pirfenidona 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

Solicitud:

pirfenidone is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.