Raw White Crystal Safe Pharmaceutical Intermediates Phenacetin Pain-Relieving Drug Phenacet Safe Pass
Quick Detail:
Product Name: Phenacetin
CAS: 62-44-2
EINECS: 200-533-0
Assay: 99%
Formula: C10H13NO2
MW: 179.2157
Density: 1.099g / cm3
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Uses: Anti-inflammatory drugs
Appearance: White or almost white crystalline powder
Export Markets: Global
Abstract
Phenacetin is a human carcinogen based on sufficient evidence of carcinogenicity studies in experimental animals. In an 18-month carcinogenicity study, dietary administration of 2.5% phenacetin induced renal cell carcinomas of the renal pelvis and transitional cell carcinomas of the urinary bladder in rats, the tumor incidence in males being greater than in females. In another long-term carcinogenicity study, dietary administration of 0.535% phenacetin for 117 weeks induced renal pelvic tumors in male rats. In B6C3F1 mice of each sex maintained on a diet containing 1.25% or 0.6% phenacetin for 96 weeks, a dose-related induction of renal tumors was observed in male mice, and urinary bladder proliferative lesions developed in mice of either sex fed 1.25% phenacetin.
Application
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetis has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treatrheumatoid arthritis (subacute type) and intercostal neuralgia.
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