Pharmaceutical Raw Materials Sex Enhancement Series Dapoxetine for Muscle Gain 119356-77-3

Pharmaceutical Raw Materials Sex Enhancement Series Dapoxetine for Muscle Gain 119356-77-3

Abstract

CAS:119356-77-3
MF:C21H23NO
MW:341.88
EINECS:1308068-626-2
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Description:

Dapoxetine is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old.Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

Dapoxetine (dapoxetine) as a new fast SSRI, a short half life, a selective 5 – HT reuptake inhibitor (SSRI), for the treatment of premature ejaculation and erectile dysfunction. Dapoxetine is a selective 5 – HT reuptake inhibitor (SSRI), such drugs widely used to treat depression and related affective disorders.

Application:

Dapoxetine is a white powder substance and water-soluble. Taken 1–3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cm) is reached 1–2 hours after oral administration.

Randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE.Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE.

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