Pharmaceutical Raw Materials Clobetasol Propionate CAS 25122-46-7 For Inflammatory Treatment Skin Disorders
Superiority
Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.
Abstract
Clobetasol propionate is part of a group of drugs known as glucocorticoids, which are a type of corticosteroid (or “steroid” for short). Although glucocorticoids have numerous effects in the body, they are used mostly for their anti-inflammatory or immune-suppressing properties. Clobetasol propionate works for most conditions by decreasing inflammation or suppressing an overactive immune system.Clobetasol propionate is a corticosteroid of synthetic steroid used to treat various skin disorders including inflammation, itching, herpes labialis, eczema, psoriasis and lichen sclerosus.Clobetasol propionate is also highly effective for contact dermatitis caused by exposure to poison ivy/oak and auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma).
Clobetasol propionate is used as first-line treatment for both acute and chronic GVHD of the skin.
Specification
| Product name |
Clobetasol propionate |
| CAS No. |
25122-46-7 |
Outer Packing |
1KG/bag |
| Production date |
2016.05 |
Shelf life |
2021.04 |
| Test |
Observation |
Limit |
| Description |
White crystalline powder |
White to cream crystalline powder |
| Solubility |
Complies |
As per USP |
| Identification |
Complies |
As per USP |
| Melting range |
196ºC |
About 196ºC |
| Specific optical Rotation(on dried basis) |
+100.92° |
+98° to +104° |
| Loss on drying |
0.25% |
Not more than 2.0% |
| Residue on ignition |
0.06% |
Not more than 0.1% |
| Heavy Metals |
Complies |
Not more than 20 ug/gm |
Chromatographic purity
i)Any individual impurity
Ii)Total impurity |
0.36%
0.58% |
Not more than1.0%
Not more than2.5% |
| Assay(on dried basis) |
99.4% |
Not less than97.0%&Not more than102.0% |
Residualsolvents
Methylene chloride
Acetone
Ethyl Acetate
Methanol
DMF |
N.D.
N.D.
N.D.
928.86ppm
N.D.
N.D. |
Not more than 600 ppm
Not more than 5000 ppm
Not more than 5000 ppm
Not more than 3000 ppm
Not more than200 ppm
Not more than 880 ppm |
Application
Adrenal corticosteroids and adrenocorticotropic hormone drugsClobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis,[4] psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.
Usage
1. For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe
corticosteroid-responsive dermatoses of the scalp.
2. Topical corticosteroid. Glucocorticoid; anti-inflammatory
How it works
Clobetasol belongs to a class of drugs called topical corticosteroids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Clobetasol works by decreasing your body’s response to inflammation. It also reduces the activity of your immune system. This prevents inflammation and itching and treats your skin condition.
Before using clobetasol cream:
Some medical conditions may interact with clobetasol cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have measles, tuberculosis (TB), chickenpox, shingles, or have had a recent vaccination
if you have a skin infection or thinning of the skin (atrophy)
Some MEDICINES MAY INTERACT with clobetasol cream. However, no specific interactions with clobetasol cream are known at this time.
Ask your health care provider if clobetasol cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
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