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Autres produits en vente chaude (Poudre brute)

» Autres produits en vente chaude (Poudre brute)

  • Trilostane Highly Potent Active Pharmaceutical Ingredients 13647-35-3 For Breast

    CATÉGORIE ET ​​ÉTIQUETTES:
    Autres produits en vente chaude (Poudre brute)
    Numéro de modèle : 13647-35-3
    Attestation : ISO 9001, USP,BPF
    Lieu d'origine : Chine
    MOQ : 10g
    Prix : négociation
    Modalités de paiement : Western union, MoneyGram, T/T, Bitcoin
    Capacité d'approvisionnement : Masse en stock
    Heure de livraison : 3~5 jours ouvrés
    Détails de l'' emballage : Colis bien déguisé ; Fût en plastique avec expédition sécurisée
    Nom du produit : Trilostane
    Autre nom : Modrenal
    Point de fusion : 264 °C
    Température de stockage. : -20°C Congélateur
    Usage : antifungal, inhibits mitosis in metaphase
    Propriétés chimiques : Tan Crystals
    demande
    • Caractéristiques

    Pharmaceutical Raw Materials Trilostane For Breast Cancer Treatment

    Détail rapide:

    Trilostane

    N ° CAS.: 13647-35-3

    Pureté: 98.5%min

    MF: C20H27NO3

    EINECS No.: 237-133-0

    Apparence: White to off-white power

    Type: Antineoplastic Agents

    Grade Standard: Qualité médicale

    Emballage: As customers requirments

    Usage: Anti-tumor drugs and immunosuppressants

    La description

    Trilostane, that is 4α, 5α-epoxy-2-cyano-3,17β-diol, can reversibly inhibit 3β-hydroxy steroid dehydrogenase and △5, 4-isomerase in the adrenal cortex to block the biosynthesis of mineralocorticoid and glucocorticoid. Dans 1980, it was approved for the treatment of hyperaldosteronism and cortisol excess disease in the United Kingdom. Dans 1985, it was approved for the treatment of Cushing’s syndrome in the United States, which is adrenal cortex hyperactivity disorder. In view of the older animals, especially older dogs are susceptible to Cushing’s syndrome. Trilostane can relieve the disease symptoms of more than 90% of dogs, and improve their quality of life. So the drug has also been granted for the treatment of animals in the United Kingdom. Trilostane itself has no hormonal activity. Its side effects is less, and its safety and tolerability are also particularly good.

    Application

    1) Trilostane,The anti estrogen steroids drug Trilostane was previously available in the United Kingdom for use in humans under the brand name Modrenal for the treatment of Cushing’s disease and for breast cancer. It was approved in the United States in 2008 for the treatment of Cushing’s disease (hyperadrenocorticism) in dogs under the brand name Vetoryl.

    2) It was available by prescription in the UK under the Vetoryl brand name for some time before it was approved in the US. The drug is also used to treat the skin disorder Alopecia X in dogs. It is also the first drug approved to treat both pituitary- and adrenal-dependent Cushing’s in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands.

    3) Trilostane,The anti estrogen steroids drug Vetoryl is used to treat Cushing’s syndrome (also known as Cushings disease or hyperadrenocorticism). This is a hormone problem associated with abnormally high levels of cortisone in the blood stream of affected dogs. The main symptoms caused are excessive thirst and hunger. It also affects the dog’s appearance and reduces its quality of life. Dogs may show hair loss, weight gain, lethargy, loss of bladder control and a bloated stomach.

    4) Trilostane,Cushing’s disease is a condition that will be present in the dog’s system for the rest of its life and will need to be treated continually. Vetoryl tackles this problem in the pituitary and adrenal glands. Cortisol levels are reduced which leads to a reduction in symptoms and Vetoryl can make a difference in just three months.

    5) Trilostane,The capsules are available in four strengths depending on the size of the dog and should only be prescribed by a vet. There are a number of contra-indications which should be taken into consideration prior to treatment. Dogs that are pregnant or who have problems with the liver or kidneys should not take this medication.

    Les indications

    Trilostane can inhibit 3β-dehydrogenase in the synthesis of corticosteroids, and decrease the synthesis of cortisol and aldosterone. It also can be used in the treatment of Cushing’s syndrome (hypercortisolism) and primary aldosteronism. But the efficacy to treat Cushing’s syndrome (hypercortisolism) is not as metyrapone. This product also has a significant role in lowering blood testosterone levels, which may be related with that its synthesis is inhibited.

    Treatment of Cushing’s syndrome

    Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders.
    Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.

    The treatment of advanced breast cancer

    Breast cancer is the most common type of tumor in women. Currently, for postmenopausal patients with hormone receptor-positive or unknown, clinical treatments unanimously recommend to be the preferred antiestrogen therapy, and the role of this therapy in delaying disease progression and improving survival time also has been affirmed and confirmed in numerous studies of breast cancer.

    Trilostane (trade name Modrenal) developed by the biotechnology company has already been on the market. It can be used for the treatment of postmenopausal women that hormone-selective cancer has spread outside the breast. The pharmaceutical uses two ways to slow down the disease progression. For hormone-sensitive breast cancer, estrogen promotes the growth of cancer cells by acting to the two receptors. Estrogen receptor α is cancer accelerator, and estrogen receptor β is the brake. Modrenal strengthens estrogen adsorption to the estrogen receptor β, and weakens the adsorption to estrogen receptor α. Meanwhile it also acts on another loci AP1in cell DNA to reduce cell proliferation.

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    Expédition & Livraison

    1. Packages are generally dispatched within approximately 24 hours after receipt of payment.

    2. After the each shipping we will provide you with:

    1) A link & tracking number to track your package online.

    2) the few pictures with your order & des détails.

    3. About the Custom clearance, we packed in disguise ways. In our experience,the appropriate and safe delivery, there won’t be problems.

    4. Nous confirmons 99% autorisation, 100% re-sending.

    5. Is it the best & safest shipping for all our repeat customers!

    Principale raison pour laquelle vous nous choisissez ?

    (1) Livraison rapide et discrète avec un grand succès d'expédition!

    (2) Photos avec votre commande & des détails!

    (3) Nous vous fournirons le numéro de suivi!

    (4) Keep track of your goods until the goods are sent in to your hands.

    (5) Nous confirmons 99% autorisation,100% re-sending.

    (6) Haute qualité, 100% produits purs!

    (7) Delivery time approx 3-5 business days.

    (8) Meilleur, Services sûrs et sécurisés.

    (9) Service client 24/7.

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