Tetracaine HCl CAS 136-47-0 Anesthetic Pain Killer Drug
Informations de base.
Nom du produit: Tétracaïne HCl
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
EINECS: 205-248-5
Mp: 149°C
Storage temp.: Réfrigérateur
Propriétés chimiques: White Solid
Usage: A local anesthetic used topically in opthalmology.
Pureté: 99%
Tetracaine HCl Description
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tétracaïne (AUBERGE, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
COA for the Tetracaine
| Articles de test |
spécification |
Résultats de test |
| Apparence |
Fine, blanche, crystalline, odorless powder |
confirm |
| Identification |
A\B\C in Pass |
confirm |
| Solubilité |
Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene |
confirm |
| USP Reference standards |
USP Tetracaine Hydrochloride RS.
USP Endotoxin RS. |
confirm |
| Point de fusion |
145~150 degree |
146.0~147.5 degree |
| Chromatographic purity |
In Pass |
confirm |
| Related substance |
Not more than the reference solution 0.05% |
confirm |
| Métaux lourds |
10 ppm |
confirm |
| PH |
4.5-6.5 |
5.8 |
| Résidu à l'allumage |
≤0.10% |
0.05% |
| Perte au séchage |
≤ 0.5% |
0.19% |
| Essai |
98.0 -101.0% |
100.1% |
| Conclusion |
Confirms USP 32 |
Directeur commercial