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Research has shown that MK-677 amplifies chemical signals directed to the pituitary gland to secrete growth hormone increasing overall growth hormone and it also acts to slow the release of somatostatin which essentially turns off the release of growth hormone. Because its powerful androgenic activity it essential changes the way androgen receptors function. Research has shown MK-677 increases not only muscle mass but also bone density and is shown to increase fat loss. Research has shown that MK-677 can also improve endurance partially because it chemically stimulates a hormone known as ghrelin which is responsible for the distribution and rate of energy use. IGF-1 which aids in protein synthesis among other things is also released at an increased rate with MK-677 Above all Research has shown MK-677 acts on various different hormonal plasma levels for sustainable long lasting increases. Research has shown that MK-677 produces many great benefits with endurance, lean mass, fat loss, increase in the healing ligaments and tendons, tightens loose skin, and promotes an overall sense of well-being.

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MK-677 is a product which acts as a potent, orally active GH secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin.
Administration of MK-677 25 mg resulted in a 60.1% increase in serum IGF-1 levels at 6 weeks and a 72.9% increase at 12 mois. In mixed-effects models that included treatment, time (month), randomization strata (baseline MMSE score ≤20 vs >20), and interaction of treatment-by-time, there were no significant differences between the treatment groups on the CIBIC-plus or the mean change from baseline scores on the ADAS-Cog, ADCS-ADL, or CDR-sob scores over 12 mois.