Raw Material Anabolic Steroids Series Fluoxymesterone / Halotestin 76-43-7

Raw Material Anabolic Steroids Series Fluoxymesterone / Halotestin 76-43-7

Abstrait

CAS:76-43-7
MF:C20H29FO3
MW:336.44
EINECS:200-961-8
Point de fusion:240 °C
alpha 104 º (c=1,EtOH)
température de stockage. ?20°C
solubility H2O: ≤0.5 mg/mL
form solid (photosensitive)
color white
Water Solubility NEGLIGIBLE
Merck 13,4212

La description:

Fluoxymesterone also exerts its effects on strength and fat loss by both regulation of fatty acid oxidation in the liver and fast-twitch muscle mitochondria . Oddly, for a drug which exerts such a nice anabolic effect, and promotes such good strength gains, Halotestin has a pretty low Androgen Receptor Binding affinity .. I suppose, in this respect it can be compared to Winstrol (Stanozolol).
As far as strength and agression goes, Halo is a great drug. Halotestin is especially useful on a cutting or strength cycle. Its use for mass and weight gains have been pretty disappointing for most users, toutefois.

Application:

1. Androgenic activity

Fluoxymesterone has a relatively high ratio of androgenic to anabolic activity similarly to testosterone.[citation requise] Like many 17α-alkylated AAS, it has relatively low affinity for the androgen receptor (AR). Cependant, its actions are mediated by the AR, most likely due to its relatively long elimination half-life of approximately 9.2 heures. It is approximately five times as potent as an AAS as testosterone. Unlike testosterone, fluoxymesterone has a 100% oral bioavailability, as the methylation of the C17α position of fluoxymesterone inhibits hepatic metabolism by enzymatic oxidation of 17β-hydroxyl, allowing its absorption into the bloodstream for transport around the body.
2. 11β-HSD inhibitor
Fluoxymesterone has been found to act as a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) (IC50 = 60–630 nM), with a potency comparable to that of the 11β-HSD2 inhibitor glycyrrhetinic acid. This unique action of fluoxymesterone is likely related to its 11β-hydroxyl group. 1β-HSD2 is responsible for the inactivation of the glucocorticoids cortisol and corticosterone (into cortisone and 11-dehydrocorticosterone, respectively). Inhibition of 11β-HSD2 by fluoxymesterone may result in mineralocorticoid receptor overactivation and associated side effects such as hypertension and fluid retention, and has been hypothesized to be involved in the cardiovascular and other adverse effects of fluoxymesterone.
3. Glucocorticoid activity
Unlike other AAS, fluoxymesterone has structural features in common with corticosteroids, including its 9α-fluoro and 11β-hydroxy groups. In accordance, it has weak (micromolar) but potentially clinically significant affinity for the glucocorticoid receptor.

What is Halotestin?

Fluoxymester one (Halotestin) works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.

Since the effects of castration in premenopausal women are far superior to those of androgenic therapy, the male hormones have been employed primarily for women of postmenopausal age.

Halotestin is used only occasionally because other hormonal therapy medicines such as and the aromatase inhibitors are generally more effective. Male breast cancer accounts for about 1% of all breast cancers.

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