Antiepileptic Pharmaceutical Raw Materials Lamotrigine CAS 84057-84-1 For Treatment of Epilepsy And Bipolar Disorder
Supériorité
Zhongshan Latterson Biotechnology Co., Ltd., est une entreprise pharmaceutique complète, qui s'est spécialisé dans la technologie biopharmaceutique 7 années. L'entreprise est située dans la ville de Zhongshan, Province de Guangdong , Chine.
Notre usine couvre une superficie de 33500 mètres carrés, avec un environnement propre et une belle mise en page. Il existe plusieurs ateliers de grande ou moyenne taille et un centre d'assurance qualité et de recherche avec un équipement de pointe. Maintenant, nos principaux produits sont des séries de stéroïdes anabolisants, Série peptidique, Série d'anesthésie locale. Nos produits atteignent le niveau avancé du marché intérieur, dont beaucoup atteignent la norme internationale, les certificats contiennent: KASCHER , ISO 9001:2008 , BPF , SGS.
Nom du produit |
Lamotrigine |
Synonymes |
4-Triazine-3,5-Diamine,6-(2,3-Dichlorophenyl)-2;
3,5-Diamino-6-(2,3-Dichlorophenyl)-1,2,4-Triazine;
6-(2,3-Dichlorophenyl)-1,2,4-Triazine-3,5-Diamine;Lamictal;Lamotrigin |
CAS |
84057-84-1 |
MF |
C9H7Cl2N5 |
MW |
256.09 |
EINECS |
281-901-8 |
Propriétés chimiques |
White to Cream Coloured Powder |
Category |
API |
Point de fusion |
177-181C |
Qualité standard |
EP/USP |
Place Of Origin |
Chine |
Application |
Pharmaceutical raw materials |
La description:
Lamotrigine, originally marketed as Lamictal and available under many brands worldwide, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression.
For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type II.
Lamotrigine is a synthetic phenyltriazine with anti-epileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake.
It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. en outre, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver .
Application:
For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
Biological Activity:Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na + , K + and Ca 2+ currents.
Lamotrigine Medical uses
Epilepsy
Lamotrigine is approved in the US for the treatment of partial seizures. It is considered a first-line drug for primary generalised tonic-clonic seizures (includes simple partial, complex partial and secondarily generalised seizures), and as an adjuvant therapy in partial seizures (focal onset tonic-clonic, atypical absence, myoclonic, and due to Lennox-Gastaut syndrome). As well, it is used as an alternative drug for absence seizure and atypical absence, myoclonic, and atonic seizures.
Lamotrigine is one of a small number of FDA-approved therapies for seizures associated with Lennox-Gastaut syndrome, a severe form of epilepsy. Typically developing before four years of age, LGS is associated with developmental delays. There is no cure, treatment is often complicated, and complete recovery is rare. Symptoms include the atonic seizure (also known as a “drop attack”), during which brief loss of muscle tone and consciousness cause abrupt falls. Lamotrigine significantly reduces the frequency of LGS seizures, and is one of two medications known to decrease the severity of drop attacks.Combination with valproate is common, but this increases the risk of lamotrigine-induced rash, and necessitates reduced dosing due to the interaction of these drugs.
Bipolar disorder
Lamotrigine is approved in the US for maintenance treatment of bipolar I disorder. While traditional anticonvulsant drugs are predominantly antimanics, lamotrigine is most effective for preventing the recurrent depressive episodes of bipolar disorder. The drug seems ineffective in the maintenance of current rapid-cycling, acute mania, or acute depression in bipolar disorder; toutefois, it is effective at prevention of or delaying the mania, depressive, or rapid cycle. According to studies in 2007, lamotrigine may treat bipolar depression without triggering mania, hypomania, mixed states, or rapid-cycling.
certificat d'authenticité:
Article |
Conditions |
Résultats de test |
La description |
A white or almost white crystalline powder |
Conforme |
Solubilité |
Soluble in methanol, very slightly soluble in acetone and isopropanol . |
Conforme |
Point de fusion |
215°C~ 219°C |
217°C~218°C |
apparence de la solution |
5.0% solution in DMF should be clear |
Conforme |
Perte au séchage |
≤ 0.5% |
0.03% |
Résidu à l'allumage |
≤ 0.1% |
0.04% |
Métaux lourds |
≤ 20ppm |
Conforme |
Residual solvent |
|
|
Methanol |
≤ 1000ppm |
Conforme |
Éthanol |
≤ 1000ppm |
Conforme |
Any other individual impurity: |
≤ 0.1% |
Conforme |
Impuretés totales |
≤ 1.0% |
Conforme |
Essai |
99.0%-101.0% |
99.70% |
Conclusion |
Meets the Requirements |
Notre service
1.100% La politique de réexpédition est notre base commerciale. 100% de réexpédition immédiatement si votre colis reste en douane pendant 4 jours et n'est pas mis à jour.
2.Remboursement total pour 15 jours d'insatisfaction avec la qualité.
3.Nous pouvons fournir des échantillons gratuits.
4.Nous avons un emballage spécial ,Il peut être facilement passé à la douane. Il sera plus sûr.
5.Notre société coopère à long terme avec DHL.EMS.Fedex et ainsi de suite. Il peut être envoyé à votre main plus rapidement. La photo du colis doit être offerte dans les 12 heures suivant la réception de votre paiement de stéroïdes.
6.Si vous avez la chance de venir en Chine. Je peux te montrer notre labo.
7.Notre société a WU, MG, TT, et les moyens de paiement Bitcoin à l'avance. Vous pouvez payer 95% pour les peptides coûtent au début pour la commande, le reste peut nous offrir dans votre prochaine commande;
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