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  • CAS 84057-84-1 Pharmaceutical Raw Materials Lamotrigine For Bipolar Disorder

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    Other Hot-Sale Products (Raw Powder)
    Model Number : CAS: 84057-84-1
    Certification : GMP,SGS,ISO9001:2008,KOSHER
    Place of Origin : China
    MOQ : 10g
    Price : Negotiable
    Payment Terms : Western Union, MoneyGram, Bank Transfer, Bitcoin
    Supply Ability : 3000KG/Month
    Delivery Time : Usually within 7 work days
    Packaging Details : Stealth and discreet packaging
    Product Name : Lamotrigine
    CAS : 84057-84-1
    MF : C9H7Cl2N5
    MW : 256.09
    EINECS : 281-901-8
    appearance : White to Cream Coloured Powder
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    • Specifications

    Antiepileptic Pharmaceutical Raw Materials Lamotrigine CAS 84057-84-1 For Treatment of Epilepsy And Bipolar Disorder

    Superiority

    Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
    Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.

    Product Name Lamotrigine
    Synonyms 4-Triazine-3,5-Diamine,6-(2,3-Dichlorophenyl)-2;

    3,5-Diamino-6-(2,3-Dichlorophenyl)-1,2,4-Triazine;

    6-(2,3-Dichlorophenyl)-1,2,4-Triazine-3,5-Diamine;Lamictal;Lamotrigin

    CAS 84057-84-1
    MF C9H7Cl2N5
    MW 256.09
    EINECS 281-901-8
    Chemical Properties White to Cream Coloured Powder
    Category API
    Melting point 177-181ºC
    Quality Standard EP/USP
    Place Of Origin China
    Application Pharmaceutical raw materials

    Description:

    Lamotrigine, originally marketed as Lamictal and available under many brands worldwide, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression.
    For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type II.

    Lamotrigine is a synthetic phenyltriazine with anti-epileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake.
    It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver .

    Application:

    For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.
    Biological Activity:Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na + , K + and Ca 2+ currents.

    Lamotrigine Medical uses
    Epilepsy
    Lamotrigine is approved in the US for the treatment of partial seizures. It is considered a first-line drug for primary generalised tonic-clonic seizures (includes simple partial, complex partial and secondarily generalised seizures), and as an adjuvant therapy in partial seizures (focal onset tonic-clonic, atypical absence, myoclonic, and due to Lennox-Gastaut syndrome). As well, it is used as an alternative drug for absence seizure and atypical absence, myoclonic, and atonic seizures.
    Lamotrigine is one of a small number of FDA-approved therapies for seizures associated with Lennox-Gastaut syndrome, a severe form of epilepsy. Typically developing before four years of age, LGS is associated with developmental delays. There is no cure, treatment is often complicated, and complete recovery is rare. Symptoms include the atonic seizure (also known as a “drop attack”), during which brief loss of muscle tone and consciousness cause abrupt falls. Lamotrigine significantly reduces the frequency of LGS seizures, and is one of two medications known to decrease the severity of drop attacks.Combination with valproate is common, but this increases the risk of lamotrigine-induced rash, and necessitates reduced dosing due to the interaction of these drugs.

    Bipolar disorder
    Lamotrigine is approved in the US for maintenance treatment of bipolar I disorder. While traditional anticonvulsant drugs are predominantly antimanics, lamotrigine is most effective for preventing the recurrent depressive episodes of bipolar disorder. The drug seems ineffective in the maintenance of current rapid-cycling, acute mania, or acute depression in bipolar disorder; however, it is effective at prevention of or delaying the mania, depressive, or rapid cycle. According to studies in 2007, lamotrigine may treat bipolar depression without triggering mania, hypomania, mixed states, or rapid-cycling.

    COA:

    Item Requirements Test Results
    Description A white or almost white crystalline powder Complies
    Solubility Soluble in methanol, very slightly soluble in acetone and isopropanol . Complies
    Melting point 215°C~ 219°C 217°C~218°C
    Appearance of solution 5.0% solution in DMF should be clear Complies
    Loss on drying ≤ 0.5% 0.03%
    Residue on ignition ≤ 0.1% 0.04%
    Heavy metals ≤ 20ppm Complies
    Residual solvent
    Methanol ≤ 1000ppm Complies
    Ethanol ≤ 1000ppm Complies
    Any other individual impurity: ≤ 0.1% Complies
    Total impurities ≤ 1.0% Complies
    Assay 99.0%-101.0% 99.70%
    Conclusion Meets the Requirements

    Our service

    1.100% reshipment policy is our business basic.100% reshipment immediately if your parcel stays Customs for 4 days and doesn’t get updated.
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    5.Our company have a long term cooperate with DHL.EMS.Fedex and so on .It can be sent to your hand more quickly. Parcel photo should be offered within 12hours after receiving your steroid payment.
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    7.Our company has WU, MG, TT, and Bitcoin payment ways in advance.You can pay 95% for the peptides cost at first for order, the rest can offer us in your next order;

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