Anti – Paining Local Anesthetic Prilocaine Safe Pass
Nom du produit: Prilocaïne
Alias:2- (propylamino) propa-namide; Prilocaine base (Propylamino) propion-o-toluidide;
CAS: 721-50-6
EINECS: 211-957-0
Formule moléculaire: C13H20N2O
Masse moléculaire: 220.31
InChI: InChI = 1 / C13H20N2O / c1-4-9-14-11 (3) 13 (16) 15-12-8-6-5-7-10 (12) 2 / h5-8,11,14H, 4, 9H2, 1 to 3H3, (H, 15, 16)
Structure moleculaire: prilocaine 721-50-6
Water-soluble: soluble in water and ethanol, slightly soluble in chloroform
Propriétés:
nature:
Needle crystal. The temperature of 37-38 °C, the boiling point of 159-162 °C (0.133 kPa), indice de réfraction (nD20) 1.5299. The hydrochloride salt ([1786-81-8]) was a white crystalline powder. Point de fusion 167-168 °C. Soluble in water and ethanol, slightly soluble in chloroform. Pickle astringent bitter, inodore.
Applications
Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics.
Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.
Prilocaine Descriptions:
Prilocaine cream is a local anesthetic. It works by blocking nerves from transmitting painful impulses to the brain.
As Prilocaine has low cardiac toxicity, Prilocaineis commonly used for intravenous regional anaesthesia (IVRA).
In some patients, ortho-toluidine, a metabolite of prilocaine, may cause methemoglobinemia, which may be treated with methylene blue. Prilocaine may also be contraindicated in people with sickle cell anemia, anemia, or symptomatic hypoxia.
People with pseudocholinesterase deficiency may have difficulty metabolizing this anesthetic.
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