Top Quality White Peptide Powder Follistatin 344 For Muscle Growth

Beschreibung

Follistatin 344 / FST was initially identified as a follicle-stimulating hormone inhibiting substance found in ovarian follicular fluid. FST is a high-affinity activin binding protein that can act as an activin antagonist. Two alternatively spliced follistatin mRNAs exist, encoding mature FS with 288 amino acid residues (FS-288) und 315 aa residues (FS-315). Natural FS purified from porcine ovaries is primarily a carboxy-terminal truncated form of FS-315 composed of 300 aa residues.

Follistatin 344 / FST quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene acts on similar pathways as FST regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting.

FST is a single chain gonadal protein that specifically inhibits follicle stimulating hormone release. The single FST gene encodes two isoforms Follistatin 317 and Follistatin 344 enthaltend 317 und 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. There is evidence linking polycystic ovary syndrome and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. It specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone. Subunit : Monomer Subcellular Location : Secreted. Tissue Specificity : Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.

Anwendung:

Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Die cDNA von menschlichem Follistatin kodiert für a 344 Aminosäure (aa) Protein mit a 29 aa Signalfolge, an Nterminal atypical TGF binding domain, drei Follistatin-Domänen, die EGF-ähnliche und Kazal-ähnliche Motive enthalten, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors.

It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (Follikelstimulierendes Hormon). Abgesehen davon, dass er ein natürlicher Antagonist ist, Follistatin kann die Aktivität anderer TGF-Beta-Liganden einschließlich BMP-2 hemmen, -4, -6, -7, Myostatin, GDF-11, und TGF-Beta1. Follistatin wird in der Hypophyse exprimiert, Eierstöcke, decidual cells of the endometrium, und in einigen anderen Geweben. Rekombinantes menschliches Follistatin ist ein 37.8 kDa protein containing 344 Aminosäuren .