Synonyms: (6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione;Amino Tadalafil;Amino Tadalafil (6R,12Ar)-2-Amino-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1′,2′:1,6]Pyrido[3,4-B]Indole-1,4-Dione;Amino Tadanafil;(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indol-1,4-dione
Safety Statements 24/25
HS Code 29339900
Abstract
A high-pressure liquid chromatography-diode array detection and multi-mode ionization tandem mass spectrometry (HPLC-DAD-MMI-MS/MS) method was used to identify amino-tadalafil and rimonabant in electronic cigarette (e-cigarette) cartridges. Amino-tadalafil is a drug analogue of the commercially approved ™ (i.e. tadalafil). Rimonabant is a drug that was, at one time, approved for weight loss in Europe (although approval has been retracted), but not in the United States. In addition, poor quality control over the e-cigarette products analyzed here is shown by the presence of nicotine in products labeled as containing no nicotine or by the presence of significant amounts of rimonabant oxidative degradant in e-cigarette products containing rimonabant. Identification was accomplished by comparing the retention time of relevant peaks in the sample with those of standard compounds, in addition to comparison of the UV spectra, mass spectra and/or product ion mass spectra.
What the medication is for and how it works?
Cialis contains the approved active ingredient known as Tadalafil with a proven history of safety and efficiency.
This type of medicine is known as a phosphodiesterase type 5-inhibitor. It is used to help men with difficulty in having and maintaining an erection which is commonly known as impotence.
It can also be used to relieve the symptoms of an enlarged prostate gland. Cialis/Tadalafil works by preventing the action of a chemical in the body called phosphodiesterase type 5.
Cialis/Tadalafil exerts its action by enhancing the effects of one of the chemicals the body normally released into the penis during sexual arousal. This allows an increase in blood flow to the penis. An erection is a result of the increase in blood flow into certain internal areas of the penis.
Specification
Items |
Specification |
Results |
Appearance |
White or almost white powder |
White powder |
Solubility |
Practically insoluble in water, freely soluble in
dimethyl sulfoxide, slightly soluble in methylene chloride |
conform |
Identification |
IR,UV |
Positive |
Special optical rotation (dried substance) |
78.0 to +84.0 |
81.0° |
Impurities A, B and C |
Impurity A: ≤0.15% |
0.01% |
Specified impurities: ≤0.10% |
conform |
relative substance |
Unspecified impurities: ≤0.10% |
0.09% |
Total impurity: ≤0.3% |
0.17% |
Loss on drying |
≤0.5% |
0.20% |
Sulfated ash |
≤0.1% |
0.06% |
Assay (on dried basis) |
97.5%~102% |
99.57% |
Applications
1. Made of natural soybean oil residue extraction. Is the cell membrane of the active material, especially
exists in the brain cells.
2. The main function is to improve the function of nerve cells, adjust the transmission of nerve impulses,
enhance memory function, due to its strong lipotropy, absorbed quickly through the blood brain barrier
into the brain, help relax vascular smooth muscle cells, increase the role of brain blood flow.
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