Applications:
Sildenafi citrate, sold as Viagras, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).used in the treatment of penile erectile dysfunction (ED).
The primary indication of sildenafi is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.People on antidepressants may experience sexual dysfunction, either as a result of their illness or as a result of their treatment.
Pharmaceutical Raw Materials Sildenafei Citrate Powder 171599-83-0
Specifications:
Items |
Standard |
Results |
Assay by HPLC |
98% |
99.37% |
Appearance |
White fine powder |
Complies |
Odor & taste |
Slight bitter |
Complies |
Mesh size |
100% pass 80mesh |
Complies |
Solubility |
Soluble in water |
Complies |
Loss on drying |
≤2.0% |
1.15% |
Heavy metals PPM |
<30ppm |
Complies |
Microbiology:
Total Plate Count:
Yeast & Mold:
E.Coli:
S. Aureus:
Salmonella: |
<1000cfu/g
<100cfu/g
Negative
Negative
Negative |
800cfu/g
90cfu/g
Complies
Complies
Complies |
Conclusion |
Conform with USP 32 |
Application:
1. Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett.
2. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.
3. In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, dyspepsia, nasal congestion and impaired vision, including photophobia and blurred vision.Some sildenafil users have complained of seeing everything tinted blue (cyanopsia).Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases and a number of studies have linked sildenafil use with nonarteritic anterior ischemic optic neuropathy.
4. Rare but serious adverse effects found through postmarketing surveillance include priapism, severe hypotension, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. As a result of these postmarketing reports, in October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss.
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