обнаружены как антагонисты активина, активность которых подавляет экспрессию и секрецию: 137525-51-0 обнаружены как антагонисты активина, активность которых подавляет экспрессию и секрецию
Краткая информация:
Псевдоним: Боули защитный состав 15, Пентадекапептид, БПЦ 157
КЕЙС: 137525-51-0
Последовательность: Гли-Глу-Про-Про-Про-Гли- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
MF: C62H98N16O22
МВт: 1419.53552
Чистота: 99%
Появление: Белый лиофилизированный порошок
Method of Analysis: ВЭЖХ
Хранилище: Лиофилизированные пептиды, хотя и стабильны при комнатной температуре в течение 3 месяцы, следует хранить в сухом виде при температуре ниже -18°C. Upon
reconstitution of the peptide it should be stored at 4° C between 2-21 дней и для дальнейшего использования при температуре ниже -18° C.
Описание:
БПЦ 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. По факту, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease. БПЦ 157 was shown to accelerate wound healing and to have a marked angiogenic effect. Он регулирует гонадотропную секрецию и дифференцировку вольфова протока., it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect. БПЦ 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.
FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
заявка:
БПЦ 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models,it may become an important therapeutic tool for the treatment of inflammatory bowel disease.BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.And it significantly facilitates the healing of bone fracture in rats,exhibits an osteogenic effect significantly improving the healing of segmental bone defect.BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle,significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.
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