Тартрат ривастигмина высокой чистоты для лечения болезни Альцгеймера
Краткая информация
Product Name Rivastigmine Tartrate
Rivastigmine Tartrate Alias Rivastigmine-d6 tartarate
Rivastigmine Tartrate CAS 129101-54-8
Rivastigmine Tartrate MF C18H28N2O8
Rivastigmine Tartrate MW 400.4235
Rivastigmine Tartrate Purity 99%
Rivastigmine Tartrate MP 123-125°C
Rivastigmine Tartrate BP 316.2°C at 760 мм рт. ст.
Rivastigmine Tartrate FP 145°C
Фармацевтический класс
Appearance White Powder
Rivastigmine Tartrate is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson’s disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting.
Абстрактный
(1) Rivastigmine is mainly through hydrolysis cholinesterase metabolism, cytochrome P450 isozymes are rarely involved in its metabolism. Следовательно, the product and by other drugs metabolized by these enzymes does not exist pharmacokinetic interactions.
(2) study in healthy volunteers found the product (a single dose of 3mg) with digoxin, warfarin, diazepam or fluoxetine, have no pharmacokinetic interactions. Warfarin induced by prothrombin time extension are not affected by this product. After combination of digoxin and the product found no adverse impact on cardiac conduction.
(3) In clinical studies of patients with Alzheimer’s disease (ОБЪЯВЛЕНИЕ), the goods and some commonly used prescription drugs combined, such as antacids, antiemetics, hypoglycemic agents, β-blockers, calcium channel blockers agents, inotropic agents, anti-angina drugs, non-steroidal anti-inflammatory drugs, estrogens, analgesics, tranquilizers, antihistamines, и т. д., and risk of clinically relevant adverse reaction does not increase
(4) In view of the pharmacokinetic effect of this product, this product should not be used in combination with other cholinergic drugs, it may interfere with the activity of anticholinergic drugs.
(5) There is no experience of this product with anti Parkinson drugs, anti anxiety drugs (except for stability), antipsychotic drugs, antiepileptic drugs, antidepressant drugs.
(6) rivastigmine tartrate as a cholinesterase inhibitor, during anesthesia, it can be used to enhance succinylcholine-type muscle relaxant effect.
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