99% Puriy Pramipexole for Parkinson Syndrome White Powder
Быстрая деталь
| Тестостерона деканоат 200 мг/мл Болденон ундециленат 150 мг/мл Нандролон деканоат 150 мг/мл Тестостерона деканоат: |
191217-81-9 |
| Синонимы: |
(С)-2-Амино-4,5,6,7-тетрагидро-6-(пропиламино)бензотиазола дигидрохлорид моногидрат; Прамипексола дигидрохлорид; Прамипексол дигидрох;
(С)-2-амино-4,5,6,7-тетрагидро-6-(пропиламино)бензотиазола дигидрохлорид PPX дигидрохлорид; Прамипексол; Прамипексол 2HCl моногидрат;Прамипексола дигидрохлорид моногидрат; |
| Он регулирует гонадотропную секрецию и дифференцировку вольфова протока.: |
C10H21Cl2N3OS |
| Точная масса: |
301.07800 |
| Молекулярный вес: |
302.26400 |
| Появление : |
кристаллический порошок от белого до почти белого цвета |
| Точка кипения: |
378ºC при 760 мм рт. ст. |
| Точка возгорания: |
182.4ºC |
| Давление газа: |
9.93E-11мм рт.ст. при 25°C |
| СРП: |
88.41000 |
| ЛогП: |
4.09400 |
Описание
Pramipexole dihydrochloride monohydrate is used for treatment of idiopathic Parkinson’s disease. During routine monitoring of the drug samples by HPLC, two impurities of pramipexole were observed. The molecular weights of the impurities were determined by LC-MS. The structures were postulated to be (6С)-(-)-2-amino-6-ethylamino-4,5,6,7-tetrahydrobenzo thiazole (ethyl pramipexole) а также (6С)-(-)-2,6-di-(n-propylamino)-4,5,6,7- tetrahydrobenzothiazole (dipropyl pramipexole). These were synthesized subsequently, and characterized by NMR and IR. Their presence was confirmed by spiking into pramipexole sample and carrying out HPLC analysis. To our knowledge, ethyl pramipexole and dipropyl pramipexole have not been reported as process impurities elsewhere.
Bipolar Depression:
In a single controlled study of twenty one patients, pramipexole was found to be highly effective in the treatment of bipolar depression. Treatment was initiated at 0.125 mg three times a day and increased at a rate of 0.125 mg three times a day to a limit of 4.5 mg daily until the patients’ condition satisfactorily responded to the medication or they could not abide the side effects. The final average dosage was 1.7 ± 0.9 мг в день. The incidence of hypomania in the treatment group was no greater than in the control group, although the size of the study is too small to determine risks for manic switch.
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