Raw Materials Hair Loss Treatment Drug Minoxidil for Lowering Blood Pressure
Basic info:
| Product Name |
Minoxidil |
| Synonyms |
6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide; 2,4-Diamino-6-piperidino-pyrimidine-3-oxide; (2E)-6-amino-2-imino-4-(piperidin-1-yl)pyrimidin-1(2H)-ol; 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide |
| Molecular Formula |
C9H15N5O |
| Molecular Weight |
209.2483 |
| InChI |
InChI=1/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12) |
| CAS |
38304-91-5 |
| EINECS |
253-874-2 |
| Density |
1.521g/cm3 |
| Boiling point |
544.931C at 760 mmHg |
| Refractive index |
1.724 |
| Flash point |
283.364C |
| Vapour Pressure |
0mmHg at 25C |
| Assay |
99% |
| Appearance |
White or white crystalline powder |
Medical uses:
Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in people with androgenic alopecia regardless of sex.About 40% of men experience hair regrowth after 3-6 months.Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth.
Its effect in people with alopecia areata is unclear.
Mechanism of action:
The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes. Hypothetically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicles. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. Several studies demonstrated that the activity of sulfotransferase in hair follicles predict minoxidil response in the treatment of hair loss.
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