Pharmaceutical Raw Materials Phenacetin 62-44-2 For Relieving Pain

Pharmaceutical Raw Materials Phenacetin 62-44-2 For Relieving Pain

Abstract

CAS:62-44-2
MF:C10H13NO2
MW:179.22
EINECS:200-533-0
Melting point:133-136 °C(lit.)
Boiling point:132 °C / 4mmHg
Density 1.1248 (rough estimate)
refractive index 1.5710
Flash point:2℃
storage temp. 2-8°C
form powder
color White
Water Solubility 0.076 g/100 mL
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Stability:Stable. Incompatible with strong oxidizing agents, strong acids.
InChIKeyCPJSUEIXXCENMM-UHFFFAOYSA-N

Description

Based on sufficient evidence for the carcinogenicity of experimental animals, acetophenone is a human carcinogen. In a 18-month carcinogenicity study, 2.5% acetophenone in the diet induced pyelonephrosis and transitional cell carcinoma of the bladder in rats, and the incidence of male cancer was higher in women than in women. In another long-term carcinogenicity study, male rat pelvic tumors were induced using 0.535% acetophenone in a 117-week diet. In each gender of B6C3F1 mice, 1.25% or 0.6% of acetophenone was included in the 96-week diet, and dose-related renal tumor induction was observed in male mice, while mice of any sex were observed. Among them, mice fed with 1.25% acetophenone developed bladder proliferative lesions.

Applicant

It has smooth leaflets or scaly crystals with no odor or taste.
Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in water
Ether, soluble in ethanol and chloroform. It is formed by etherification, reduction and acetylation.
The reaction of p-chloronitrobenzene. Such as chloroacetanilide antipyretic analgesic. Suitable for fever,
A drug such as headache or neuralgia is used as a compound preparation.
Antipyretic effect is stronger than analgesic effect. The strength effect is as slow, long lasting and low toxicity as aspirin. Studies have shown that this product and its metabolites have an antipyretic effect on acetaminophen. Since the enzyme inhibitor can not convert acetophenone into paracetamol, it still shows obvious antipyretic effect, so the antipyretic effect after the product series cannot be converted into paracetamol. The mild phenacetin analgesic effect usually lasts for 3 to 4 hours; and synergizes with salicylic acid to enhance the analgesic effect. Mainly used for antipyretic analgesia in small animals. This product is also an integral part of the APC tablet.

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