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Pharmaceutical Raw Materials Minoxidil Hair Loss Supplements 38304-91-5

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Abstract

CAS:38304-91-5
MF:C9H15N5O
MW:209.25
EINECS:253-874-2
Melting point:272-274 °C (dec.)(lit.)
Boiling point:348.61°C (rough estimate)
Density 1.1651 (rough estimate)
refractive index 1.7610 (estimate)
storage temp. Store at RT
pka4.61(at 25℃)
Water Solubility Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck 14,6203

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Pharmaceutical Raw Materials Minoxidil Hair Loss Supplements 38304-91-5

Abstract

CAS:38304-91-5
MF:C9H15N5O
MW:209.25
EINECS:253-874-2
Melting point:272-274 °C (dec.)(lit.)
Boiling point:348.61°C (rough estimate)
Density 1.1651 (rough estimate)
refractive index 1.7610 (estimate)
storage temp. Store at RT
pka4.61(at 25℃)
Water Solubility Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck 14,6203

Description

Minoxidil is a potassium channel agonist. It contains the chemical structure of nitric oxide, a vasodilator, and may be a nitric oxide agonist. This may seem to explain its vasodilation, but it may also be related to the ability of minoxidil to stimulate hair growth and treat hair loss. Since minoxidil is a compound associated with nitric oxide, it is suspected to act by activating a guanylate cyclase, an enzyme involved in vasodilation.

Minoxidil is a vasodilator known for its ability to slow or prevent hair loss and promote hair regeneration. In the treatment of androgenetic alopecia and other baldness treatments, it can be bought on the counter, but within a few months after stopping treatment, the measurable changes disappear. Its effectiveness has been proven in young men (18 to 41 years old), the younger the better, as well as in bald men in the scalp center (apex)

Applicant
Minoxidil is the first FDA-approved drug for the treatment of androgenetic alopecia (hair loss). Prior to this, minoxidil was used as a vasodilator for the treatment of hypertension, and its side effects include hair growth and male baldness. In the 1980s, UpJohn Corporation introduced a topical solution of 2% minoxidil, called Rogaine, for the special treatment of androgenetic alopecia.
COA
Product Name MINOXIDIL Lot no 20180605
MFG. Date 2018.06.08 Issued Date 2018.06.10
Quantity 1054KG Expiry date 2018.06.09
Test Items Specification Test Results
APPEARANCE WHITE OR OFFWHITE POWDER WHITE OR OFFWHITE POWDER
IDENTIFICATION POSITIVE POSITIVE
RESIDUE ON IGNITION ≤0.5% 0.05%
HEAVY METALS ≤20ppm 5ppm
LOSS ON DRYING ≤0.5% ≤0.16%
ORGANIC VOLATILE IMPURITIES ACCORD WITH USP32 ACCORD WITH USP32
TOTAL IMPURITIES ≤1.5% ≤0.5%
ASSAY(HPLC) 97~103% 99.38%
Conclusion THE PRODUCT CONFORMS TO USP32
Director:Zhu Ruhui Tester:Miao Qing Retester Liu Zixuan

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