Peptide Steroid Hormones DSIP Delta Sleep
Quick Details
Name: DSIP (Delta sleep-inducing peptide)
Sequence: r-l-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Specification: 2mg/vial;
CAS: 62568-57-4
Formula: C35H48N10O15
Molecular Weight: 848.81
Purity: 99.5%min
Acetate Content (HPIC): ≤15.0%
MS(ESI): Consistent
Abstract
Delta sleep-inducing peptide (DSIP) and P-DSIP, phosphorylated analogue, were found to have enhancing effects on hypothermia induced by i.p. injection of apomorphine (2 mg/kg), a dopamine agonist. Further, the action of P-DSIP appeared and diminished more quickly than that of DSIP. A minimal effective dose of these peptides was 10 ng and the dose-response relationship exhibited an inverted bell-shape with a maximal effective dose of 1 microgram. By the pretreatment of anti-DSIP the enhancing effect of DSIP but not P-DSIP, was totally abolished and the action of both peptides was antagonized by haloperidol. These findings suggest that DSIP and P-DSIP have a close relation to the dopaminergic system on the thermoregulatory mechanisms.
DSIP Application:
1. Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
2. Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.
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