Olaparib AZD2281 Raw Pharmaceutical Materials For Cancer CAS 763113-22-0

Superiority
Zhongshan Latterson Biotechnology Co., Ltd., is a comprehensive pharmaceutical enterprise, which specialized in bio-pharmaceutical technology over 7 years. The company is located in Zhongshan City, Guangdong Province , China.
Our factory covers an area of 33500 square meters, with clean environment and nice layout. There are several large or medium workshops and QA and research center with advanced equipment. At present, our main products are Anabolic Steroid series, Peptide series, Local Anesthetic series. Our products reach the advanced standard of domestic market, many of which reach the international standard, certificates contain: KOSHER , ISO 9001:2008 , GMP , SGS.

Basic Details :
Product Name: Olaparib
Synonyms: 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]Methyl]-1(2H)-phthalazinone;KU 59436;AZD2281(olaparib)/AZD-2281;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]piperazin;Olaparid AZD2281;Olaparib (AZD2281, Ku-0059436);Olaparid
CAS :763113-22-0
MF: C24H23FN4O3
MW: 434.46
Solubility (25°C) : DMSO 86 mg/mL warming (197.94 mM) Water 0.002 mg/mL (0.0 mM) Ethanol <1 mg/mL
Stability :-20ºC Powder , 3 years : -80ºC Soluble in solvents 2years
Usage:Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.

Application:

Ovarian cancer is formed in the ovaries, which is one of the female gonads formed by ovaries.Lynparza is a poly ADP-ribose polymerase (PARP) inhibitor that blocks enzymes involved in repairing damaged DNA. It is suitable for the treatment of BRCA gene defects associated with ovarian cancer pretreatment in severely women.

Today’s approval is the first of a new class of drugs to treat ovarian cancer,” said Dr. Richard Pazdur, director of the Institute of Hematology and Oncology at the FDA’s Center for Drug Evaluation and Research in the United States. “Lynparza was approved for specificity of the BRCA gene Abnormal patients, and how to better understand the underlying disease mechanisms can lead to targeted, more personalized treatment.

Description:

Olapanil is a novel poly-ADP ribose polymerase (PARP) inhibitor, including PARP1, PARP2 and PARP3. PARP-mediated mechanism of DNA repair plays an important role in DNA damage repair and apoptosis. Thus, the mechanism of DNA damage repair by targeted cells is a key vulnerability mediated by PARP1 and PARCA2 mutant cancer cells, which can be used for breast cancer susceptibility gene (BRCA) mutations, platinum-sensitive patients with recurrent severe ovaries Cancer maintenance therapy.

Olaparib is a novel ADP-ribose polymerase (PARP) inhibitor, including PARP1, PARP2 and PARP3. PARP-mediated DNA repair mechanism plays an important role in DNA damage repair and apoptosis, and therefore olaparib specifically targets targeted DNA repair mechanisms for DNA repair by attacking BRCA1 mutations in cancer cells with critical fragility, BRCA2 The Because of this mechanism, it can be used for maintenance treatment with patients with severe recurrent ovarian cancer who are susceptible to breast cancer susceptibility gene (BRCA) mutations and platinum-sensitive drugs.

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1.100% reshipment policy is our business basic.100% reshipment immediately if your parcel stays Customs for 4 days and doesn’t get updated.
2.Total refund for 15 days of dissatisfaction with quality.
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