9-Fluorenol is also known as hydrafinil and is the next generation of cognitive stimulants shown to be 39% more effective than moda-finil in maintaining alertness. It is 140% as efficacious as moda-finil at wakefulness promotion and does not have the same interactions as moda-finil. It also does not last as long, making it easier to dose more effectively, without having to wait out 12 hours of effects. It has slightly lower DAT affinities but had higher eugeroic actions. It is more potent than moda-finil with 50-100mg corresponding to 100-200mg for moda-finil. It shows no toxicity and no liver interactions.
Mechanisms of Action:
The precise mechanism of action is still unknown. However, a few possible mechanisms have been proposed. Firstly, it is believed that Hydrafinil (Fluorenol) may function as a weak dopamine reuptake inhibitor, which means that it increases the levels of dopamine neurotransmitter. As a result, a number of cognitive processes are improved.
Secondly, it has been hypothesised that Hydrafinil (Fluorenol) acts as a serotonin 5-HT6 receptor antagonist. 5-HT6 receptors are located in the central nervous system (CNS) and it appears that their blockage can lead to improvements of cognitive performance in many different learning and memory paradigms.2 In addition, serotonin and its system plays a very important role in both cognitive and behavioural control. Therefore, some of the mild mood improvements reported following the use of Hydrafinil (Fluorenol) are attributed to this system.
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