Nootropic SARM Steroids Powder Coluracetam BCI – 540 CAS 135463-81-9

What is Coluracetam?

Coluracetam, as known as MKC-231 has been classed as a nootropic agent. It’s known to enhance cognitive effects, based on the ways in which it influences choline uptake. Originally developed to treat Alzheimer’s disease, Coluracetam was found to be more effective as a nootropic and is purely marketed as a cognitive enhancer.

It is one of the newer racetam nootropics to reach the market. Since Coluracetam enhances levels of choline in the brain and body, it increases the production of acetylcholine. Without acetylcholine, we wouldn’t be able to remember the simplest of facts or move our muscles. It’s been reported that Coluracetam not only increases acetylcholine levels but also speeds up its flow.

Quick Detail

Description

Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease.

Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown

Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.

Application

Memory and Learning

Coluracetam is shown to improve cognitive function and memory in rats, and in theory, the same results are expected in human beings. A study conducted by BrainCells Inc, showed a memory improvement in rats who were given substance AF64A (a neuron-specific neurotoxin) for 8 days along with Coluracetam in 3mg doses. These rats were put through the standardized Morris Water Maze to mark their ability to get through it, and even up to 72 hours after the last 8mg dose, they were still able to. Another key finding of this study was that the results were still apparent 3 days after the last dose, even though the serum concentration of Coluracetam was negligible.

Depression and Anxiety

BrainCells Inc, found that a dosage of 240mg (split into three daily doses of 80mg) was useful in treating major depression co-morbid with GAD (generalized anxiety disorder). However, the differences were most pronounced in those who didn’t find relief in using standard antidepressants. After one dose, there were no noticeable differences, but after 2 doses at 80mg, 36% had improved scores during a depression assessment test.

Eyesight

Coluracetam has been associated with optic benefits such as enhanced color vision, recognition and vividness. Although there isn’t any conclusive evidence to support the mechanisms behind this benefit, experts believe that Coluracetam works in the part of the brain that runs visual processes.

COA of Coluracetam/ MKC-231 Powder

Coluracetam DOSING

Since the study subjects were mainly rats, there isn’t any recommended human dosages, but there is a general guideline for conversion.

In rats, the dosage ranged between 1 mg/kg and 10 mg/kg per day. By using allometric scaling, the dose becomes 2.9 mg/kg in humans, so the average dose should not exceed 203.5 mg daily for someone in a typical weight class.

There isn’t very much information to indicate toxicity of Coluracetam, although doses given at the above increments showed no negative side effects. If you haven’t used a nootropic before, you may develop headache after use, which is a common in first time users. By stacking the Coluracetam with Choline, you’ll reduce this risk.

Coluracetam Functions

1. Enhance mental intelligence
2. Boost memory and leaning capabilities
3. Improve brain power to solve problems and protect it from any chemical or physical injury
4. Enhance motivation level
5. Enhance the control of cortical/subcortical brain mechanism
6. Improve sensory perception    

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