Nootropic Raw Materials Powder Sunifiram / Piperazine, 1-benzoyl-4-(1-oxopropyl)- Pharmaceutical Chemical

CAS: 314728-85-3

MF: C14H18N2O2

MW: 246.30492

Synonyms: Piperazine, 1-benzoyl-4-(1-oxopropyl)-;SunifiraM;1-(4-Benzoyl-1-piperazinyl)-1-propanone;1-Benzoyl-4-(1-oxopropyl)-piperazine;1-(4-Benzoylpiperazin-1-yl)propan-1-one;1-Benzoyl-4-propanoylpiperazine;Sunifiram DM235

Density 1.154±0.06 g/cm3 (20 ºC 760 Torr)

solubility H2O: soluble24mg/mL

color white

Abstract

This compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.

Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).

Sunifiram operates by activating AMPA receptors; that is, the receptors that are responsible for the mediation of synaptic transmission in the central nervous system. Its mechanics also increases phosphorylation of AMPAR and NMDAR through protein kinase activation, which in turn enhances long-term potentiation – that is, an enhancement in signal transmission between two neurons resulting from simultaneous stimulation.

The kinase activation that is influenced by Sunifiram also improves cognitive defects. Additionally, Sunifiram works in the cerebral cortex of animal test subjects by assisting in the release of acetylcholine, the organic molecule that acts as a neurotransmitter in a host of various organisms. These operational mechanisms enable Sunifiram to exert anti-amnesiac properties.

COA

Sunifiram, also known as 1-benzoyl-4-propanoylpiperazine is a nootropic that was only first researched in the year 2000.

It has a similar chemical structure to Piracetam but initial studies show that it is significantly more potent than this widely used racetam.

Sunifiram so far shows very positive results as memory enhancer and it is currently being investigated for potential treatment of Alzheimer’s and other diseases related to cognitive decline.

User reviews and Sunifiram logs point to the fact that this supplement makes information recall much easier and helps you think more clearly. Sunifiram is being compared to Noopept quite a bit because of their similar potency levels.

Initial observations suggest that Sunifiram is better as a memory booster while Noopept might have an edge on increasing focus and alertness.

How to Use

– Sunifiram is extremely potent, so small doses should be taken. It has been said that it works best when taken sublingually. This means that users place it under their tongue for administration. This will generally be a little scoop of powder. Some users have experienced a slight tingling, as you would with a breath mint. Ingestion has been reported as easy.

– Start with the smallest dose, seeing how you feel. Most users report feeling the effects within an hour of administration. You can always increase your dosage after a week or so. Since dosing is still being studied, do not exceed 10 mg. Use it sparingly or choose to cycle your doses. This means that you will cycle ‘on’ and ‘off.’ —Spreading out your doses over the course of the week, and then taking a break.

– When purchasing online, you may notice that Sunifiram costs slightly more than other nootropics. Keep in mind that the dosage is much smaller than other nootropics. You only need a little to achieve big results. This is due to the potency offered.

Function

Sunifiram activates AMPA-mediated neurotransmission.Enhancing LTP in a bell-shaped dose-response relationship.Sunifiram aids in the release of acetylcholine in the cerebral cortex.Sunifiram increases energy levels, allowing users to feel more motivated and eliminateSunifiram increase Levels of concentration increase, and users feel less distracted by external stimuli.Sunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.

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