Local Anesthetic Raw Powder Mepivacaine Hydrochloride / Mepivacaine HCL CAS 1722-62-9 For Pain Relieve
Abstract
Mepivacaine Hydrochloride, a tertiary amine used as a local anesthetic, is 1-methyl-2′, 6′ – pipecoloxylidide monohydrochloride.
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.
Pharmacodynamics
Mepivicaine is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.
COA
| Product name |
Mepivacaine HCl |
| Appearance |
White crystalline powder |
| Assay (C13H20N2O2·HCl) |
99.0% to 101.0% |
99.50% |
| Melting point |
153~158ºC |
156.5~157.0ºC |
| Heavy metals |
≤20ppm |
<5ppm |
| Acidity |
≤0.02N NaOH 0.5ml |
0.3ml |
| Chromatographic purity |
Secondary spots≤0.5%,sum≤1.0% |
Conforms |
| Loss on drying |
≤1.0% |
0.06% |
| Residue on ignition |
≤0.15% |
0.03% |
| Bacterial endotoxins |
≤0.6EU/mg |
<0.6EU/mg |
Mechanism of action
Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone.
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