Healthy Pharmaceutical Raw Materials Allopurinol CAS 315-30-0 Treating acute

Pharmaceutical Raw Material Allopurinol CAS 315-30-0 Treating acute lymphoblastic leukemia

Quick Details:

Product Name: Allopurinol

Synonyms: TIMTEC-BB SBB004202;ISOPURINOL;LABOTEST-BB LT00244764;HPP;1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL;AKOS BBS-00005290;ALLPURINOL;AKOS BBS-00002073

CAS: 315-30-0

MF: C5H4N4O

EINECS: 206-250-9

Product Categories:PYRIMIDINE;Miscellaneous Natural Products;Heterocyclic Compounds;Antitumors for Research and Experimental Use;Chemical Reagents for Pharmacology Research;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Fused Ring Systems;API’s;Miscellaneous Enzyme;Bases & Related Reagents;Nucleotides;ZYLOPRIM;inhibitor;Other APIs

Mp:>300 °C(lit.)

storage temp. Room temperature.

Water Solubility:0.35 g/L (25 ºC)

Merck :279

CAS DataBase Reference:315-30-0(CAS DataBase Reference)

NIST Chemistry Reference:Allopurinol(315-30-0)

EPA Substance Registry System:4H-Pyrazolo[3,4- d]pyrimidin-4-one, 1,5-dihydro-(315-30-0)

Hazard Codes:T,Xi,Xn

Risk Statements:25-43-36/37/38-20/21/22

Safety Statements:28-36/37-45-36/37/39-26-24-36

RIDADR:UN 2811 6.1/PG 3

WGK Germany:2

RTECS:UR0785000

HazardClass :6.1

Application:

Allopurinol is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.

Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as these regimens can rapidly produce severe acute hyperuricemia, although it has gradually been replaced by urate oxidase therapy

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