GnRH Muscle Gaining Peptides Gonadorelin Acetate 2 mg/vial Gonadorelin CAS 71447-49-9 Safe Pass
Abstract
Gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH) and luliberin, is a trophic peptide hormone responsible for the release offollicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.
GnRH is synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic-pituitary-gonadal axis.
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
Application
Gonadorelin is a medicine that is the same as gonadotropin-releasing hormone (GnRH) that is naturally released from the hypothalamus gland. GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults.
Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
Specification
| Item |
Specification |
| Specific rotation |
+39.5 to +41.5° |
| State of solution(transmittance) |
Clear 98.0% min. |
| Chloride[cl] |
0.020% max. |
| Ammonium [NH4] |
0.02% max. |
| Sulfate[SO4] |
0.020% max |
| Iron[Fe] |
10ppm max. |
| Heavy metals [Pb] |
10ppm max |
| Arsenic[As2O3] |
1ppm max |
| Other amino acids |
Chromatographically not detectable |
| Loss on drying |
0.20% max. |
| Residue on ignition[sulfated] |
0.10% max. |
| Assay |
99.0% min |
GnRH is available as gonadorelin hydrochloride )and gonadorelin diacetate tetrahydrate for injectable use. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.
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