Nootropics Active Pharmaceutical Ingredients Donepezil CAS 120014-06-4 For Brain
Supériorité
Zhongshan Latterson Biotechnology Co., Ltd., est une entreprise pharmaceutique complète, qui s'est spécialisé dans la technologie biopharmaceutique 7 années. L'entreprise est située dans la ville de Zhongshan, Province de Guangdong , Chine.
Notre usine couvre une superficie de 33500 mètres carrés, avec un environnement propre et une belle mise en page. Il existe plusieurs ateliers de grande ou moyenne taille et un centre d'assurance qualité et de recherche avec un équipement de pointe. Maintenant, nos principaux produits sont des séries de stéroïdes anabolisants, Série peptidique, Série d'anesthésie locale. Nos produits atteignent le niveau avancé du marché intérieur, dont beaucoup atteignent la norme internationale, les certificats contiennent: KASCHER , ISO 9001:2008 , BPF , SGS.
Product Details:
Nom du produit |
Donepezil |
Synonymes |
2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;
1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;
AKOS 226-23;2,3-dihydro-5,6-dimethoxy-2-((1-(phénylméthyle)-4-piperidinyl)methyl)-1h-inde;
n-1-one;N-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl] piperidine;
5,6-Dimethoxy-2,3-dihydro-1H-inden-1-one |
Essai |
99% |
n ° CAS |
120014-06-4 |
Emballage |
Customized package as you require |
MF. |
C24H29NO3 |
M.W. |
379.49 |
EINECS |
1312995-182-4 |
Point de fusion |
207°C |
Apparence |
Poudre cristalline blanche |
Marque |
Sendi |
Qualité standard |
Norme d'entreprise |
Usage |
Treatment of depression. |
La description:
Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer’s disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 heures, it can be taken once a day.
Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer’s patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.
UN 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 mois. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.
Application:
Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 heures. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, mémoire, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.
Donepezil binds and inactivates reversibly the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses. The precise mechanism of action of donepezil in patients with Alzheimer’s disease is not fully understood. Certainly Alzheimer’s disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer’s disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain. It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.
certificat d'authenticité:
TEST ITEM |
SPECIFICATION |
RESULT |
Apparence |
Off white to white crystalline powder |
Conforme |
Solubilité |
freely Freely soluble in chloroform, soluble
in water and Acetic acid, peu soluble dans
Acetonitrile and ethanol, insoluble in
Ethylacetoacetate and n-hexane |
Conforme |
Identification |
(1)By IR absorption ,To match with working
standard |
Conforme |
(2) The retention time of the major peak of
the sample should accord with that of the
working standard. |
Conforme |
(3) Test for chlorides. Reponds to the test
for Chlorides. |
Conforme |
PH |
4.0-7.0 |
6.10 |
Résidu à l'allumage |
≤0.1% |
0.03% |
Related substance |
Any Unkonwn single impurity≤0.3%
Total ≤0.5% |
0.04%
0.18% |
Heavy metal |
10 ppm |
<10ppm |
Residual Solvents |
Methanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5% |
Not detected
Not detected
Not detected
Not detected
Not detected |
Perte au séchage |
0,5 % |
0.20% |
Essai |
On dried base, C24H29NO3·HCl
should be 98.0% à 102.0% |
100.20% |
Conclusion: The product complies to Enterprise standard |
Dosage and Administration:
Allow Donepezil hydrochloride ODT to dissolve on the tongue and follow with water.
1) For Mild Moderate Alzheimer user:
Starting dosage: 5 mg administered once per day in the evening, just prior to retiring.
2) For mild to moderate Alzheimer user:
The maximum recommended dosage is 10 mg par jour.
A dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 à 6 semaines.
Notre service
1.100% La politique de réexpédition est notre base commerciale. 100% de réexpédition immédiatement si votre colis reste en douane pendant 4 jours et n'est pas mis à jour.
2.Remboursement total pour 15 jours d'insatisfaction avec la qualité.
3.Nous pouvons fournir des échantillons gratuits.
4.Nous avons un emballage spécial ,Il peut être facilement passé à la douane. Il sera plus sûr.
5.Notre société coopère à long terme avec DHL.EMS.Fedex et ainsi de suite. Il peut être envoyé à votre main plus rapidement. La photo du colis doit être offerte dans les 12 heures suivant la réception de votre paiement de stéroïdes.
6.Si vous avez la chance de venir en Chine. Je peux te montrer notre labo.
7.Notre société a WU, MG, TT, et les moyens de paiement Bitcoin à l'avance. Vous pouvez payer 95% pour les peptides coûtent au début pour la commande, le reste peut nous offrir dans votre prochaine commande;
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