High Purity Effective Diuretic Furosemide / Lasix 99% Raw Material Powder
Product Information:
Nom du produit: Furosemide
Synonymes: LABOTEST-BB LT00244801;FUROSEMID;FUROSEMIDE;FRUSEMIDE;2-
furfurylamino-4-chloro-5-sulfamoylbenzoic acid;4-CHLORO-N-FURFURYL-5-
SULFAMOYLANTHRANILIC ACID;5-(AMINOSULPHONYL)-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID;5-[AMINOSULFONYL]-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID
CAS: 54-31-9
MF: C12H11ClN2O5S
MW: 330.74
EINECS: 200-203-6
catégories de produits: Organics;Intermédiaires & Produits chimiques raffinés, produits chimiques en bon état;Médicaments;API’s;Ion
transporter and other ion channel;GABA;Aromatiques;Hétérocycles;Soufre & Selenium
Compounds;API;LASIX;Autres API
Propriétés chimiques:
Point de fusion 220 °C (dec.)(lit.)
density 1.606
Fp 11 °C
température de stockage. 2-8°C
Water Solubility Soluble in acetone, DMF or methanol. Slightly soluble in water
Merck 14,4309
Stabilité: Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.
Safety Information:
Hazard Codes T,F,Xi
Risk Statements 61-39/23/24/25-23/24/25-11-36/37/38
Safety Statements 7-16-36/37-45-53-36/37/39-22-36-26
RIDADR UN 1230 3/PG 2
WGK Germany 3
RTECS CB2625000
Usage And Synthesis:
Efficient diuretics Furosemide, is a class of efficient sulfonamide diuretics acting on themedullary loop of the ascending branch of the medulla,it has a strong and short-term diuretic effect,which can increase the excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphate and so on. It Mainly inhibits Na + and Cl-reabsorption in medullary and cortex of the medullary loop ascending branch crude segment , it can promote the excretion of sodium, chloride and potassium and affect the formation of renal medullary high osmotic pressure,it can interfer the process of concentration and dilution of urine, and it can increase urine output. This product can inhibit the activity of prostaglandin decomposition enzyme ,make the content of prostaglandin E2 increase,it has effect on expansion of blood vessels, it also plays a role in the proximal tubule, glomerular filtration,it can increase renal blood flow,and adjust renal blood flow distribution,and reduce blood flow so that the cortex surface blood flow increases,it promotes diuresis, its effect is fast and strong, it is used for other diuretics invalid cases. Clinically it is used for the treatment of cardiac edema, renal edema, cirrhosis ascitic fluid, peripheral edema caused by dysfunction or vascular disorders , and it may contribute to an upper urinary tract stones excretion. Administration intravenously can treat brain edema, it also can accelerate the excretion of toxic substances in cerebral edema in poisoning . Note that when the diuretic furosemide is used, since the excretion of urine Cl-, Na +, K +, H + is increasing, alors que the excretion of HCO3-is not increasing, long-term repeated drug use or large quantities of drugs can cause low salt syndrome, low chlorine and low potassium alkalosis.In recent years, researchers find that inhalation of furosemide can have a significant effect on asthma, it is like cromolyn sodium, which through inhibition of allergic mediator release, it can inhibit the release of the neurotransmitter acetylcholine and substance P, which may be related to inhibiting chloride ions into the cell membranes of respiratory tract. Clinically,it is used in exercise-induced asthma, immediate and delayed type antigen-induced asthma. Chemical properties white or white alike crystalline powder. 206 ℃ melting point. Dissolved in acetone, méthanol, dimethyl formamide, légèrement soluble dans l'éthanol, insoluble dans l'eau. Odorless, almost tasteless. Uses The diuretic effect of this product is a strong and short,it is a potent diuretic for the treatment of edema caused by heart, liver, kidney and other diseases, in particular, the base cases which other diuretics are invalid to;it can be used to treat acute pulmonary edema, brain edema , acute renal failure and high blood pressure and other diseases; in combination with fluid infusion, le product can promote poison excretion. Rat oral LD50 is 2600-2820mg/kg.production method 2,4-dichlorobenzoic acid (see 12740) by sulfochlorination,ammoniation, acidification ,dichloro-5-sulfamoyl-benzoic acid is obtained. Then after condensation with the chaff amine , furosemide is produced.
Category Toxic substances
Toxicity grading Middle toxic
Acute toxicity Oral-rat LD50: 2600 mg/kg; Oral-Mouse LD50: 2200 mg/kg.
Flammability and hazard characteristics Combustible; fire decomposition produces toxic nitrogen oxides; sulfur oxides and chlorides smoke.Storage Characteristics Ventilated, low-temperature ,dry storeroom.Extinguishing agent Water, carbon dioxide, dry powder,sandy soil. Chemical Properties white to light yellow crystal powde Uses diuretic, antihypertensive Uses Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic. Uses This compound belongs to the aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.Uses An inhibitor of NKCC and a GABAA receptor antagonist. General Description Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless. Air & Water Reactions Light sensitive. Air sensitive. Slightly soluble in water.Reactivity Profile Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of Furosemide. Incompatible avec les agents oxydants forts .Fire Hazard Flash point data for Furosemide are not available; toutefois, Furosemide is probably combustible. Biological Activity Loop diuretic that inhibits the Na + /2Cl – /K + (NKCC) cotransporter. Also acts as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-containing receptors than α 1-containing receptors.
Notre service
1.100% La politique de réexpédition est notre base commerciale. 100% de réexpédition immédiatement si votre colis reste en douane pendant 4 jours et n'est pas mis à jour.
2.Remboursement total pour 15 jours d'insatisfaction avec la qualité.
3.Nous pouvons fournir des échantillons gratuits.
4.Nous avons un emballage spécial ,Il peut être facilement passé à la douane. Il sera plus sûr.
5.Notre société coopère à long terme avec DHL.EMS.Fedex et ainsi de suite. Il peut être envoyé à votre main plus rapidement. La photo du colis doit être offerte dans les 12 heures suivant la réception de votre paiement de stéroïdes.
6.Si vous avez la chance de venir en Chine. Je peux te montrer notre labo.
7.Notre société a WU, MG, TT, et les moyens de paiement Bitcoin à l'avance. Vous pouvez payer 95% pour les peptides coûtent au début pour la commande, le reste peut nous offrir dans votre prochaine commande;
Autres produits en vente chaude (Poudre brute) |
TUDCA (Acide tauroursodésoxycholique) |
GBL (Y-Butyrolactone) |
1,4-Butanediol |
Minoxidil |
Mélatonine |
Trétinoïne |
Sunifiram |
Prégabaline |
Phénacétine |
Paracétamol |
Lévamisole HCL |
Pirfénidone |
Épinéphrine HCL |
Prégnénolone |
Bromhydrate de dextrométhorphane monohydraté |
Argireline |
SNAP-8 1mg/flacon |
Théophylline |
Diclofénac sodique |
Sel de sodium de tianeptine |
Noopept |
Mononucléotide bêta-nicotinamide |
Propionate de clobétasol |
polyéthylène glycol(CHEVILLE) |
Kétoprofène |
1,3-Chlorhydrate de diméthylbutylamine |
Polyvinylpyrrolidone |
Baricitinib |
Diprophylline |
Aminophylline |
Tianeptine |