Healthy Pharmaceutical Raw Materials Allopurinol CAS 315-30-0 Treating acute

Pharmaceutical Raw Material Allopurinol CAS 315-30-0 Treating acute lymphoblastic leukemia

Détails rapides:

Nom du produit: Allopurinol

Synonymes: TIMTEC-BB SBB004202;ISOPURINOL;LABOTEST-BB LT00244764;HPP;1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL;AKOS BBS-00005290;ALLPURINOL;AKOS BBS-00002073

CAS: 315-30-0

MF: C5H4N4O

EINECS: 206-250-9

catégories de produits:PYRIMIDINE;Miscellaneous Natural Products;Heterocyclic Compounds;Antitumors for Research and Experimental Use;Chemical Reagents for Pharmacology Research;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucléotides & Réactifs associés;Hétérocycles;Intermédiaires & Produits chimiques raffinés, produits chimiques en bon état;Médicaments;Fused Ring Systems;API’s;Miscellaneous Enzyme;Socles & Réactifs associés;Nucléotides;ZYLOPRIM;inhibitor;Autres API

Mp:>300 °C(lit.)

température de stockage. Room temperature.

Solubilité dans l'eau:0.35 g/L (25 C)

Merck :279

CAS DataBase Reference:315-30-0(CAS DataBase Reference)

NIST Chemistry Reference:Allopurinol(315-30-0)

EPA Substance Registry System:4H-Pyrazolo[3,4- ré]pyrimidin-4-one, 1,5-dihydro-(315-30-0)

Hazard Codes:T,Xi,Xn

Risk Statements:25-43-36/37/38-20/21/22

Safety Statements:28-36/37-45-36/37/39-26-24-36

RIDADR:UN 2811 6.1/PG 3

WGK Germany:2

RTECS:UR0785000

HazardClass :6.1

Application:

Allopurinol inhibits the breakdown (catabolism) of the thiopurine drug mercaptopurine, and was specifically invented by Gertrude Elion to enhance the action of mercaptopurine in the treatment of acute lymphoblastic leukemia. Cependant, no improvement in leukemia response was noted with mercaptopurine-allopurinol cotherapy, and this use of the drug was abandoned.

Allopurinol is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.

Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as these regimens can rapidly produce severe acute hyperuricemia, although it has gradually been replaced by urate oxidase therapy

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