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Raw Materials Beta-Nicotinamide Mononucleotide

CATEGORÍA Y ETIQUETAS:
Otros productos de venta caliente (Polvo crudo)
Certificación: YO ASI, 9001, USP
Número de modelo: 1094-61-7
Cantidad mínima de pedido: 10gramos
El tiempo de entrega: dentro 2 días laborables
Términos de pago: T/T in advance, Pago de Pequeña Cantidad, Western Union, Transferencia bancaria.
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Raw Materials Beta-Nicotinamide Mononucleotide

 

Detalle rápido


Nombre del producto β-NMN, Mononucleótido de beta-nicotinamida
β-NMN CAS: 1094-61-7
β-NMN Assay: 99.5%
β-NMN MF: C11H15N2O8P
β-NMN MW: 334.22
β-NMN EINECS: 214-136-5
β-NMN storage temp. 2-8° C
β-NMN Chemical Properties: polvo blanco.
β-NMN Payment: T / T, Western Union y MoneyGram
β-NMN Delivery: Dentro de las 24 horas posteriores a su pago
β-NMN Express: EMS, DHL, FedEx, etc.(door-to-door)

 

Beta-Nicotinamide Mononucleotide Application

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (nmn) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.

NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity. Genetically engineered mice lacking NMNAT1 die during early embryogenesis, indicating a critical role of this gene in organismal viability.[citation needed] In contrast, mice lacking NMNAT2, which is expressed predominantly in neural tissues, complete development but die shortly after birth. Sin embargo, NMNAT1 is dispensable for cell viability, as homozygous deletion of this gene occurs in glioblastoma tumors and cell lines. NMNAT enzymatic activity is probably essential at the cellular level, as complete ablation of NMNAT activity in model organisms leads to cellular inviability.

 

Solicitud

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (nmn) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.

NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity. Genetically engineered mice lacking NMNAT1 die during early embryogenesis, indicating a critical role of this gene in organismal viability.[citation needed] In contrast, mice lacking NMNAT2, which is expressed predominantly in neural tissues, complete development but die shortly after birth. Sin embargo, NMNAT1 is dispensable for cell viability, as homozygous deletion of this gene occurs in glioblastoma tumors and cell lines. NMNAT enzymatic activity is probably essential at the cellular level, as complete ablation of NMNAT activity in model organisms leads to cellular inviability.

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