Pharmaceutical Raw Steroid Powder Losartan Potassium CAS 124750-99-8 For for Hypertension Treatment
Superioridad
Zhongshan Latterson Biotechnology Co., Limitado., es una empresa farmacéutica integral, que se especializó en tecnología biofarmacéutica sobre 7 años. La empresa está ubicada en la ciudad de Zhongshan, Provincia de Guangdong , porcelana.
Nuestra fábrica cubre un área de 33500 metros cuadrados, con un ambiente limpio y un diseño agradable. Hay varios talleres grandes o medianos y un centro de investigación y control de calidad con equipos avanzados.. En el presente, Nuestros principales productos son la serie de esteroides anabólicos., Serie de péptidos, Serie de anestésicos locales. Nuestros productos alcanzan el estándar avanzado del mercado nacional., muchos de los cuales alcanzan el estándar internacional, los certificados contienen: COMESTIBLE SEGÚN LA LEY JUDÍA , YO ASI 9001:2008 , GMP , SGS.
Abstracto
Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has other downstream effects, including a correlated antagonism of the thromboxane A2 receptor, inhibition of platelet aggregation, and induction of peroxisome proliferator-actived receptor gamma (PPARγ) activity.
Solicitud
As with all angiotensin II type 1 receptor (AT1) antagonists, losartan is indicated for the treatment of hypertension. It may also delay progression of diabetic nephropathy and is associated with a positive clinical outcome in that regard. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria or proteinuria.Losartan is also available as losartan, acombination drug with a low-dose thiazide dluretic to achieve an additive antihypertensive effect.
COA
| Elementos de análisis |
Especificación |
Resultados |
| Caracteres |
White or off white crystalline powder |
off white powder |
| Solubilidad |
Free soluble in water and methanol, very slightly soluble in chloroform |
Cumple |
| Infraed absorption |
Must similar to reference standard |
Cumple |
| Ultraviolet absorption |
Must similar to reference standard |
Cumple |
| Test for potassium |
Must be positive |
positivo |
| Agua |
≤0,5% |
0.20% |
| Metales pesados |
≤10 ppm |
<10ppm |
| Single impurity |
≤0.2% |
0.07% |
| impureza total |
≤0,5% |
0.12% |
|
≤1000ppm |
|
| Isopropyl alcohol |
≤2000ppm |
234ppm |
| Ensayo |
98.5-101% |
99.8% |
| Conclusión |
Calificado |
Pharmacokinetics
1. Losartan potassium,Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5-carboxylic acid metabolite, designated as EXP3174. Acerca de 14% of an oral dosage is converted to this metabolite, which is long-acting (6 a 8 hora) and a noncompetitive antagonist at the AT1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. Losartan’s bioavailability is about 32%.
2. Losartan potassium,Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. Acerca de 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. The terminal elimination half lives of losartan and EXP3174 are about 1.5 a 2.5 hours and 3 a 9 horas, respectively.
More Details
| Indications |
| A |
Losartan Tablet is indicated for the treatment of hypertension. |
| contra indications |
| A |
Patients who are hypersensitive to any component of this product. |
| B |
Safety and efficacy has not been established in children. |
| C |
The use of Losartan Tablet during pregnancy and lactation is contra-indicated.
Losartan Tablet should be discontinued as soon as possible, when pregnancy is suspected. |
| Warnings |
| A |
Women of childbearing age should ensure adequate contraception. |
| B |
Symptomatic hypotension may occur after initiation of Losartan Tablet. |
| C |
Reduced doses must be considered in patients with hepatic impairment. |
| D |
Losartan Tablet is contra-indicated in pregnancy and should be used with care,
if at all, during breast-feeding. |
| mi |
Losartan Tablet should be used with caution in patients with bilateral renal artery stenosis
or stenosis of an artery to a single kidney, aortic valve stenosis, and hypertrophic
obstructive cardiomyopathy. |
Competitive advantages
1.Our company is a renowned pharmaceutical manufacturer, specializing in raw steroid powders in Mainland China. It is not only the leading manufacturer of steroids powder and pharmaceutical raw materials in the central area of China but also exports all over the world. All powders are factory directly supplying.
2.Our products have been exported to Germany, Noruega, Polonia, Finlandia, España, Reino Unido, Francia, Rusia, EE.UU, Brasil, Mexico, Australia, Japón, Korea, Thailand, Indonesia, Uruguay and many other countries. Monthly output is over 100kgs. We cherish a great number of loyal customers serving in gym fields, athletes fields , medical institution ,clinics and so on
3.Top quality products with the most competitive rate. Free samples are available.
4.Well disguised packing. Fast and secure delivery by DHL, TNT, FedEx, HKEMS, UPS, etc..
5.Flexible payment terms
6. Exclusive customer service and 24/7 online timely and helpful After-sale service.
Nuestro servicio
1.100% La política de reenvío es nuestro negocio básico. Reenvío del 100% inmediatamente si su paquete permanece en Aduana por 4 días y no se actualiza.
2.Reembolso total por 15 días de insatisfacción con la calidad.
3.Podemos proporcionar muestras gratis..
4.Tenemos un embalaje especial ,Se puede pasar fácilmente por la aduana.Será más seguro..
5.Nuestra empresa tiene una cooperación a largo plazo con DHL.EMS.Fedex y así sucesivamente. Se puede enviar a su mano más rápidamente. La foto del paquete debe ofrecerse dentro de las 12 horas posteriores a la recepción de su pago de esteroides.
6.Si tienes la oportunidad de venir a China. Puedo mostrarte nuestro laboratorio.
7.Nuestra empresa tiene WU, MG, TT, y formas de pago de Bitcoin por adelantado. 95% por el costo de los péptidos al principio por pedido, el resto nos lo puede ofrecer en su próximo pedido;
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