Zhongshan Latterson Biotechnology Co., Limitado.

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Bicalutamide Powder CAS: 90357-06-5 Treatment For Prostate Cancer China Factory

CATEGORÍA Y ETIQUETAS:
Otros productos de venta caliente (Polvo crudo)
Número de modelo : 90357-06-5
Certificación : GMP, SGS , YO ASI 9001:2008 , COMESTIBLE SEGÚN LA LEY JUDÍA
Lugar de origen : porcelana
MOQ : 10gramo
Precio : Negociable ( Descuentos para pedidos grandes )
Términos de pago : Western Union, MoneyGram, Transferencia bancaria, Bitcoin
Capacidad de suministro : 200 kg/mes
El tiempo de entrega : Dentro de 7 Días laborables
detalles del empaque : Embalaje sigiloso y discreto
nombre del producto : Bicalutamide
CASO : 90357-06-5
MF : C18H14F4N2O4S
MW : 430.37
Punto de fusion : 191-193° C
Apariencia : Off-white crystalline powder
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Bicalutamide Powder CAS: 90357-06-5 Treatment For Prostate Cancer China Factory

Superioridad

Zhongshan Latterson Biotechnology Co., Limitado., es una empresa farmacéutica integral, que se especializó en tecnología biofarmacéutica sobre 7 años. La empresa está ubicada en la ciudad de Zhongshan, Provincia de Guangdong , porcelana.
Nuestra fábrica cubre un área de 33500 metros cuadrados, con un ambiente limpio y un diseño agradable. Hay varios talleres grandes o medianos y un centro de investigación y control de calidad con equipos avanzados.. En el presente, Nuestros principales productos son la serie de esteroides anabólicos., Serie de péptidos, Serie de anestésicos locales. Nuestros productos alcanzan el estándar avanzado del mercado nacional., muchos de los cuales alcanzan el estándar internacional, los certificados contienen: COMESTIBLE SEGÚN LA LEY JUDÍA , YO ASI 9001:2008 , GMP , SGS.

Bicalutamide

nombre del producto: Bicalutamide
Sinónimos: (+-)–2-hydroxy-2-methyl;propanamide,norte-(4-cyano-3-(trifluorometilo)fenilo)-3-((4-fluorophenyl)sulfonyl);ICI-176334;CASODEX;BICALUTAMIDE;NORTE-[(4-CYANO-3-TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPANAMIDE;NORTE-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPIONANILIDE;Bicalutamide (Subject to patent free)
CASO: 90357-06-5
MF: C18H14F4N2O4S
MW: 430.37
EINECS:
Categorías de Producto: Active Pharmaceutical Ingredients;Antiandrogen;Antineoplastic (Hormonal);anti-neoplastic;Aromáticos;intermedios & Productos químicos finos;Productos farmacéuticos;Azufre & Compuestos de selenio;API’s;API;MODRASTANE
Archivo Mol: 90357-06-5.mol
Bicalutamide Structure
Bicalutamide Chemical Properties
Punto de fusion 191-193° C
temperatura de almacenamiento. Store at RT
solubility DMSO: >5mg / mL
λmax 270Nuevo Méjico(CH3CN)(Solución antibacteriana necesaria en alcohol bencílico de aceite esteroide)
Merck 14,1200
CAS DataBase Reference 90357-06-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Declaraciones de riesgo 36/37/38
Declaraciones de seguridad 26-36-24/25
RIDADR 3077
RTECS TX1413500
HazardClass 9
PackingGroup III
Código hs 29242995
Hazardous Substances Data 90357-06-5(Hazardous Substances Data)
MSDS Information
Provider Language
Bicalutamide English
Bicalutamide Usage And Synthesis
Bicalutamide Solubility soluble in dimethyl formamide; dissolved in tetrahydrofuran; slightly soluble in ethyl acetate and methanol; insoluble in water.
Determination of the content of Bicalutamide tablets by high performance liquid chromatography (HPLC) Using SHIMADZU CLC-ODS (150mm´6.0mm, 5μ) column. 0.1% potassium dihydrogen phosphate solution-acetonitrile (50:50) as the mobile phase, detecting at 272nm wavelength. Result: bicalutamide had a good linear relationship (r=0.9995) when the concentration in the range of 0.05mg*ml-1~0.20mg*ml-1. The average recovery was 99.5%, and RSD=0.9% (n=9 ) Conclusión: The method is simple, good accuracy and high precision.
Bicalutamide tablets Bicalutamide tablet is a non-steroidal androgen antagonist, which competes androgen receptor with the androgen, blocks cellular uptake of androgen, and inhibits the binding of androgens to the target organ. It binds with the androgen receptor that forms receptor complex, which enters the nucleus and combined with the nucleoprotein, consequently inhibiting tumor cell growth. It can be as a first-line drug for palliative treatment of advanced prostate cancer.
Dosage and administration:
Adulto: adult males including the elderly: uno (50mg), once a day. The treatment should be started simultaneously with LHRH analogue therapy or surgical orchiectomy.
Children: This product is contraindicated in children.
Renal impairment: The patients with renal impairment don’t need dose adjustment.
Hepatic impairment: The patients with mild liver damage don’t need dose adjustment, while the patients with severe liver damage may occur drug accumulation (see precautions).
Precautions:
This product is widely metabolized in the liver. Data show that patients with severe liver damage may slow down drug clearance, which may lead to accumulation. So the patients with moderate and severe liver injury should use it with caution.
The patients may appear liver changes by using it, so it should be considered regular liver function tests. The main changes generally appear within the first 6 months of treatment using this product.
Severe changes in liver function are rarely visible in the treatment of the product (see Adverse Reactions). If there is a serious change in treatment using this product, it should be discontinued.
This product is shown to inhibit the activity of cytochrome P450 (CYP3A4). When combined with drugs metabolised mainly by CYP3A4, the patients should be caution (see Contraindications and Drug Interactions).
Pregnancy and lactation: This product is contraindicated in women, especially for pregnant women or nursing mothers.
Effect on driving and operating machinery ability: This product does not affect the ability of patients of driving and operating the machine.
The above information is edited by the chemicalbook of Kui Ming.
Adverse reaction Pharmacological effects of this product caused certain expected reactions, including flushing, Comezón, in addition to breast tenderness and feminization of male breast, which can alleviate with orchiectomy. This product may also cause diarrhea, náuseas, vomiting, fatigue and dry skin.
Liver function changes (elevated levels of transaminases, ictericia) have been observed in clinical trials of this product, but there were rare serious changes. These changes are often short-lived. The changes then gradually subsided or improved whether to continue treatment or discontinuation of treatment. Patients receiving treatment of this product were very rare liver failure, and its causal relationship has not been established. Regularly check liver function should be considered. (See precautions).
During clinical studies, using this product with LHRH analogues, the following side effects were also observed (clinical investigaters thought it may be related to it and drug-related incidence greater than 1%). Side effects associated with the use of these drugs are no causal relationship, and some of them are daily inherent in the elderly.
Cardiovascular system: heart failure
Digestive system: anorexia, dry mouth, indigestion, constipation, flatulence.
Central nervous system: mareo, insomnia, somnolence, decreased sexual drive.
Respiratory system: dyspnea.
Urogenital system: impotence, nocturia.
Hematology: anemia.
Skin and its appendages: alopecia, rash, sweating, hirsutism.
Metabolism and nutrition: diabetes, hyperglycemia, peripheral edema, increased or decreased body weight.
Torso: abdominal pain, chest pain, headaches, pelvic pain, chills.
Contraindicaciones:
Contraindicated in women and children.
Can not be used in patients with allergy to the chemicals.
This product can’t use combination with terfenadine, astemizole, or cisapride.
Chemical properties Crystallization from 1: 1 (by volume) of ethyl acetate and petroleum ether. Melting point is 191~193 ℃.
Usos V1 taking anti-androgens drug. Prostate cancer therapeutic agents for the treatment of advanced prostate cancer.
Producing method methyl methacrylate epoxidized to form epoxide,and then in the presence of sodium hydride reacted with fluorothiophenol to form the compound ,followed by oxidation to form compound. Then hydrolyzed to the acid,with thionyl chloride chloride as acid chloride.And finally condensation with 4-cyano-3-trifluoromethyl-aniline to obtain the product.
Propiedades químicas Off-White Crystalline Solid
Usos adrenocortical suppressant, antineoplastic, steroid biosynthesis inhibitor
Usos Non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal)
Definition ChEBI: A sulfone that is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Biological Activity Orally active non-steroidal androgen receptor antagonist (IC 50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo .
Bicalutamide Preparation Products And Raw materials
Raw materials Methyl methacrylate–>4-Fluorothiophenol–>Expoxide–>4-Aminobenzonitrile

Nuestro servicio

1.100% La política de reenvío es nuestro negocio básico. Reenvío del 100% inmediatamente si su paquete permanece en Aduana por 4 días y no se actualiza.
2.Reembolso total por 15 días de insatisfacción con la calidad.
3.Podemos proporcionar muestras gratis..
4.Tenemos un embalaje especial ,Se puede pasar fácilmente por la aduana.Será más seguro..
5.Nuestra empresa tiene una cooperación a largo plazo con DHL.EMS.Fedex y así sucesivamente. Se puede enviar a su mano más rápidamente. La foto del paquete debe ofrecerse dentro de las 12 horas posteriores a la recepción de su pago de esteroides.
6.Si tienes la oportunidad de venir a China. Puedo mostrarte nuestro laboratorio.
7.Nuestra empresa tiene WU, MG, TT, y formas de pago de Bitcoin por adelantado. 95% por el costo de los péptidos al principio por pedido, el resto nos lo puede ofrecer en su próximo pedido;

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