Best Quality Anti-Inflammatory USP34 Tacrolimus 104987-11-3 Use in Liver Transplantation
Detalles Rápidos:
Tacrolimus
CASO: 104987-11-3
MF: C44H69NO12
MW: 804.02
Categorías de Producto:Productos farmacéuticos;Chiral Reagents;Fujimycin, Prograf;antibiotic
Propiedades químicas: White Crystalline Solid
Ensayo:99%
Uso: An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Embalaje:2g/foil bag
Descripción:
Tacrolimus is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, which are vital to the body’s learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura’s disease, and the skin condition vitiligo.
Solicitud:
Heart liver kidney and bone marrow transplant patients preferred immune-suppressing drugs after the transplant rejection resistant to conventional immunosuppressive regimen, is also the choice of the drug… Adverse reactions similar to cyclosporine. autoimmune eye disease and other autoimmune diseases also play an active role.
COA:
| Pruebas |
Especificaciones |
Resultados |
| Descripción |
A white or off-white crystalline powder |
Ajustarse |
| Identificación |
1. Y (USP <197K>) |
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|
2. HPLC retention times |
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Agua
(USP <921> Method I) |
1.6 ~ 3.0% |
2.1% |
Residuos en ignición
(USP <281>) |
£ 0.2% |
0.08% |
Metales pesados
(USP <231> II) |
£ 20 ppm |
< 20 ppm |
| Related substances (In-house HPLC method) |
Ascomycin £ 0.8% |
0.064% |
Solventes residuales
(In-house method) |
Acetone £ 2000 ppm |
No detectado |
| Ensayo (on anhydrous basis) |
98.0% ~ 102.0% |
100.0% |
| Conclusión: Complied with In-House standard |
Hexadrone es un poderoso anabólico:
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
As an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. It suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. An important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side-effects.
It is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids[citation needed]. Clinical trials of up to one year have been conducted. Recently it has also been used to treat segmental vitiligo in children, especially in areas on the face
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