Antihistamines Pharmaceutical Raw Material Loratadine Powder CAS: 79794-75-5

Superioridad

Zhongshan Latterson Biotechnology Co., Limitado., es una empresa farmacéutica integral, que se especializó en tecnología biofarmacéutica sobre 7 años. La empresa está ubicada en la ciudad de Zhongshan, Provincia de Guangdong , porcelana.
Nuestra fábrica cubre un área de 33500 metros cuadrados, con un ambiente limpio y un diseño agradable. Hay varios talleres grandes o medianos y un centro de investigación y control de calidad con equipos avanzados.. En el presente, Nuestros principales productos son la serie de esteroides anabólicos., Serie de péptidos, Serie de anestésicos locales. Nuestros productos alcanzan el estándar avanzado del mercado nacional., muchos de los cuales alcanzan el estándar internacional, los certificados contienen: COMESTIBLE SEGÚN LA LEY JUDÍA , YO ASI 9001:2008 , GMP , SGS.

nombre del producto: Loratadine
Sinónimos: LORATADINE;LORATADINE-D5;LORATIDINE;CLARATYNE;CLARITIN;ethyl 4-(8-chloro-

5,6-dihydro-11h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate;4(8

-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-

PIPERIDINECARBOXYLATE;4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-

YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
CASO: 79794-75-5
MF: C22H23ClN2O2
MW: 382.88
EINECS: 1308068-626-2
Categorías de Producto: Active Pharmaceutical Ingredients;intermedios & Fine

Chemicals;Productos farmacéuticos;API’s;Histamine receptor;Amines;heterociclos;Farmacéutico

intermedio;Other APIsMelting point 134-136°C
RTECS TM6129200
temperatura de almacenamiento. 2-8° C
solubilidad DMSO: 26 mg / mL, soluble
form powder
color white
Water Solubility It is soluble in DMSO (50 mg / ml), etanol (77 mg/ml at 25°C),agua (<1 mg/ml at 25°C), cloroformo, and methanol.
Merck 14,5578
Estabilidad: Stable, but may be heat sensitive – refrigerate. Incompatible with strongoxidizing agents.

Loratadine Usage And Synthesis

Abstract Loratadine, sold under the brand name Claritin among others.Loratadine(Claritin) is a long-acting, non-sedating antihistamine that is used for the treatment of allergies. Histamine is a chemical that causes many of the signs and symptoms of an allergy. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that we associate with allergy, including welts, Comezón, and tissue swelling. Loratadine(Claritin) blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine.

Antiallergic Loratadine is a common antiallergic medication, which is a second generation long-acting tricyclic antihistamine, rapid onset of action is strong, does not contain hormones, absorbed by the body metabolism with more active desloratadine, inhibiting histamine H1 receptor by competitively inhibit histamine-induced allergic symptoms, with no obvious anticholinergic and central inhibition. It is used for the relief of clinical symptoms of allergic rhinitis related, such as sneezing, runny nose and nasal itching, eye itching and burning. It is also used to relieve symptoms of chronic urticaria and other allergic skin diseases.

Drug Interactions Inhibition of hepatic drug-metabolizing enzyme function drugs can slow the metabolism of the product, such as itraconazole, ketoconazole, Daily with 400 mg ketoconazole suit, can make the product and its active metabolite to carboxyethyl loratadine increased plasma concentrations, but it was not observed in the changes of electrocardiogram (ECG). It can also inhibit the metabolism of loratadine when used with macrolides, cimetidine, theophylline and other drugs together.

Solicitud

Antihistamines, peripheral nerves are highly selective H1-receptor, the role of strong,long time. For allergic arthritis, allergic rhinitis.National second-class anti-allergy drugs, for the relief of seasonal allergic rhinitisnasal and non-nasal symptoms and relieve chronic urticaria.Side effects Common side effects include sleepiness, dry mouth, and headache. Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be safe but has not been well studied. It is not recommended in children less than two years old. It is in the second-generation antihistamine family ofmedication.Preparation Compound (I) (0.05mo1) was dissolved in toluene (450m1), dropwise additionof ethyl chloroformate (0.15mo1). Canada finished in the sauna heating 2h, and then stirred at room temperature overnight. Added 800ml water. The benzene layer was separated, washed with water, and dried. Decompression concentrated oil, with petroleum ether afterimpregnation with acetonitrile, recrystallization, the yield of loratadine, 64%.Chemical Properties White Crystalline Solid
Uses antinflammatory, analgésico, antipyretic
Uses Anti-histamine
Uses A nonsedating-type histamine H1-receptor
Biological Activity Peripheral histamine H 1 receptor antagonist (K i = 35 nM); devoid of central effects. Orally active antiallergic agent.

Nuestro servicio

1.100% La política de reenvío es nuestro negocio básico. Reenvío del 100% inmediatamente si su paquete permanece en Aduana por 4 días y no se actualiza.
2.Reembolso total por 15 días de insatisfacción con la calidad.
3.Podemos proporcionar muestras gratis..
4.Tenemos un embalaje especial ,Se puede pasar fácilmente por la aduana.Será más seguro..
5.Nuestra empresa tiene una cooperación a largo plazo con DHL.EMS.Fedex y así sucesivamente. Se puede enviar a su mano más rápidamente. La foto del paquete debe ofrecerse dentro de las 12 horas posteriores a la recepción de su pago de esteroides.
6.Si tienes la oportunidad de venir a China. Puedo mostrarte nuestro laboratorio.
7.Nuestra empresa tiene WU, MG, TT, y formas de pago de Bitcoin por adelantado. 95% por el costo de los péptidos al principio por pedido, el resto nos lo puede ofrecer en su próximo pedido;